Adenylosuccinate Synthase (ADSS)
[Edit]ADSS2; Adenylosuccinate synthetase isozyme 2; IMP--aspartate ligase 2; Adenylosuccinate synthetase, acidic isozyme; Adenylosuccinate synthetase, liver isozyme
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Alignment with the sequence of the ADSS gene in mouse, Dictyostelium discoideum, and E. coli pointed to invariant residues that are likely to be important for structure and/or catalysis. The human ADSS sequence also showed some similarity to argininosuccinate synthetase, which catalyzes a chemically similar reaction.
Somatic cell hybrids between human cells and Chinese hamster ovary (CHO) cells deficient in specific steps in the purine biosynthetic pathway permitted mapping of human genes correcting the defects. The ade(-)H mutant is missing the enzyme adenylosuccinate synthetase (ADSS), which carries out the first of a 2-step sequence in the biosynthesis of AMP from IMP. Thus, ade(-)H cells require exogenous adenine for growth.
Organism species: Homo sapiens (Human)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | n/a | Recombinant Adenylosuccinate Synthase (ADSS) | Recombinant Protein Customized Service Offer |
| Antibodies | n/a | Monoclonal Antibody to Adenylosuccinate Synthase (ADSS) | Monoclonal Antibody Customized Service Offer |
| n/a | Polyclonal Antibody to Adenylosuccinate Synthase (ADSS) | Polyclonal Antibody Customized Service Offer | |
| Assay Kits | n/a | CLIA Kit for Adenylosuccinate Synthase (ADSS) | CLIA Kit Customized Service Offer |
| n/a | ELISA Kit for Adenylosuccinate Synthase (ADSS) | ELISA Kit Customized Service Offer |
Organism species: Mus musculus (Mouse)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | n/a | Recombinant Adenylosuccinate Synthase (ADSS) | Recombinant Protein Customized Service Offer |
| Antibodies | n/a | Monoclonal Antibody to Adenylosuccinate Synthase (ADSS) | Monoclonal Antibody Customized Service Offer |
| n/a | Polyclonal Antibody to Adenylosuccinate Synthase (ADSS) | Polyclonal Antibody Customized Service Offer | |
| Assay Kits | SEJ670Mu | ELISA Kit for Adenylosuccinate Synthase (ADSS) | Enzyme-linked immunosorbent assay for Antigen Detection. |
Organism species: Rattus norvegicus (Rat)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | n/a | Recombinant Adenylosuccinate Synthase (ADSS) | Recombinant Protein Customized Service Offer |
| Antibodies | n/a | Monoclonal Antibody to Adenylosuccinate Synthase (ADSS) | Monoclonal Antibody Customized Service Offer |
| n/a | Polyclonal Antibody to Adenylosuccinate Synthase (ADSS) | Polyclonal Antibody Customized Service Offer | |
| Assay Kits | n/a | CLIA Kit for Adenylosuccinate Synthase (ADSS) | CLIA Kit Customized Service Offer |
| n/a | ELISA Kit for Adenylosuccinate Synthase (ADSS) | ELISA Kit Customized Service Offer |
- "Cloning and characterization of the cDNA encoding human adenylosuccinate synthetase."FEBS Lett. 303:4-10(1992) [PubMed] [Europe PMC] [Abstract]
- "The DNA sequence and biological annotation of human chromosome 1." Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
- "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
- "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
- "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
- "Human adenylosuccinate synthetase isozyme 2 in complex with GDP."Submitted (FEB-2009) to the PDB data bank