Actin Related Protein T2 (ACTRT2)

ACTRT2 belongs to the actin family. Studies have shown that this protein may be involved in cytoskeletal organization similar to other cytoplasmic actin-related protein (ARP) subfamily members. Antibody raised against the human protein has been used to detect the protein by immunoblotting and immunofluorescence microscopy, demonstrating its specific synthesis in the testis, late in spermatid differentiation, and its localization in the calyx.

The deduced 377-amino acid protein contains an actin-like ATP/ADP-binding pocket and 2 nuclear export signals. However, residues likely to be involved in actin-actin and actin-myosin contacts are not well conserved in ARPM2. ARPM2 shares 48% amino acid identity with beta-actin and 46% identity with ARPM1.