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Aconitase 2 (ACO2)

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ACONM; Citrate hydro-lyase; Aconitate hydratase, mitochondrial

Aconitase 2 (ACO2)
CCC J682
HGNC 118
MGI 87880
PubMed 22405087
RGD 621360
UniProt Q99798
Aconitase 2(ACO2) belongs to the aconitase/IPM isomerase family. It is an enzyme that catalyzes the interconversion of citrate to isocitrate via cis-aconitatAconitase 2(ACO2)e in the second step of the TCA cycle. This protein is encoded in the nucleus and functions in the mitochondrion.
It was found to be one of the mitochondrial matrix proteins that are preferentially degraded by the serine protease 15(PRSS15), also known as Lon protease, after oxidative modification. Frataxin interacted with aconitase in a citrate-dependent fashion, reduced the level of oxidant-induced inactivation, and converted the inactive [3Fe-4S]1+ enzyme to the active [4Fe-4S]2+ form of the protein.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Aconitase 2 (ACO2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Aconitase 2 (ACO2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Aconitase 2 (ACO2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Aconitase 2 (ACO2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Aconitase 2 (ACO2) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Aconitase 2 (ACO2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Aconitase 2 (ACO2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Aconitase 2 (ACO2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Aconitase 2 (ACO2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Aconitase 2 (ACO2) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Aconitase 2 (ACO2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Aconitase 2 (ACO2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Aconitase 2 (ACO2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Aconitase 2 (ACO2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Aconitase 2 (ACO2) ELISA Kit Customized Service Offer
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  2. "A genome annotation-driven approach to cloning the human ORFeome."Genome Biol. 5:R84.1-R84.11(2004) [PubMed] [Europe PMC] [Abstract]
  3. "The DNA sequence of human chromosome 22." Nature 402:489-495(1999) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. , Submitted (DEC-2008) to UniProtKB
  6. "Purification and partial amino acid sequence of human aconitase."Protein Seq. Data Anal. 4:63-67(1991) [PubMed] [Europe PMC] [Abstract]
  7. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
  8. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  9. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  10. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  11. "The consensus coding sequences of human breast and colorectal cancers." Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract]
  12. "Infantile cerebellar-retinal degeneration associated with a mutation in mitochondrial aconitase, ACO2."Am. J. Hum. Genet. 90:518-523(2012) [PubMed] [Europe PMC] [Abstract]