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Apoptotic Chromatin Condensation Inducer 1 (ACIN1)

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ACN; ACINUS; fSAP152; Functional Spliceosome-Associated Protein 152; Apoptotic chromatin condensation inducer in the nucleus

Apoptotic Chromatin Condensation Inducer 1 (ACIN1)
CCC J685
HGNC 17066
MGI 1891824
PubMed 17409846
RGD 1311945
UniProt Q9UKV3
Wiki ACIN1
Apoptosis is defined by several unique morphologic nuclear changes, including chromatin condensation and nuclear fragmentation. These changes are triggered by the activation of a family of cysteine proteases called caspases , and caspase-activated DNase (CAD/DFF40) and lamin protease have been implicated in some of these changes. CAD/DFF40 induces chromatin condensation in purified nuclei, but distinct caspase-activated factor(s) may be responsible for chromatin condensation.
Immunodepletion experiments showed that acinus is essential for apoptotic chromatin condensation in vitro, and an antisense study revealed that acinus is also important in the induction of apoptotic chromatin condensation in cells.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Apoptotic Chromatin Condensation Inducer 1 (ACIN1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Apoptotic Chromatin Condensation Inducer 1 (ACIN1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Apoptotic Chromatin Condensation Inducer 1 (ACIN1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Apoptotic Chromatin Condensation Inducer 1 (ACIN1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Apoptotic Chromatin Condensation Inducer 1 (ACIN1) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Apoptotic Chromatin Condensation Inducer 1 (ACIN1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Apoptotic Chromatin Condensation Inducer 1 (ACIN1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Apoptotic Chromatin Condensation Inducer 1 (ACIN1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Apoptotic Chromatin Condensation Inducer 1 (ACIN1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Apoptotic Chromatin Condensation Inducer 1 (ACIN1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Apoptotic Chromatin Condensation Inducer 1 (ACIN1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Apoptotic Chromatin Condensation Inducer 1 (ACIN1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Apoptotic Chromatin Condensation Inducer 1 (ACIN1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Apoptotic Chromatin Condensation Inducer 1 (ACIN1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Apoptotic Chromatin Condensation Inducer 1 (ACIN1) ELISA Kit Customized Service Offer
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  19. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  20. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
  21. "Human SAP18 mediates assembly of a splicing regulatory multiprotein complex via its ubiquitin-like fold."RNA 16:2442-2454(2010) [PubMed] [Europe PMC] [Abstract]
  22. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  23. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
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  25. "Proteins associated with the exon junction complex also control the alternative splicing of apoptotic regulators."Mol. Cell. Biol. 32:954-967(2012) [PubMed] [Europe PMC] [Abstract]
  26. "The structure of the ASAP core complex reveals the existence of a Pinin-containing PSAP complex."Nat. Struct. Mol. Biol. 19:378-386(2012) [PubMed] [Europe PMC] [Abstract]
  27. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
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