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ATP Citrate Lyase (ACLY)

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ATPCL; CLATP; ACL; ATP-citrate synthase; Citrate cleavage enzyme

ATP Citrate Lyase (ACLY)
CCC J686
HGNC 115
MGI 103251
PubMed 18922930
RGD 2018
UniProt P53396
Wiki ACLY
ATP citrate lyase is an enzyme that represents an important step in fatty acid biosynthesis.ATP citrate lyase is the primary enzyme responsible for the synthesis of cytosolic acetyl-CoA in many tissues. The enzyme is a tetramer of apparently identical subunits. The product, acetyl-CoA, serves several important biosynthetic pathways, including lipogenesis and cholesterogenesis. It is activated in by insulin.
The enzyme is composed of two subunits in green plants, species of fungi, Glaucophytes, Chlamydomonas, and prokaryotes.Animal ACL enzymes are homomeric, presumably an evolutionary fusion of the ACLA and ACLB genes probably occurred early in the evolutionary history of this kingdom.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant ATP Citrate Lyase (ACLY) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to ATP Citrate Lyase (ACLY) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to ATP Citrate Lyase (ACLY) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for ATP Citrate Lyase (ACLY) CLIA Kit Customized Service Offer
n/a ELISA Kit for ATP Citrate Lyase (ACLY) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant ATP Citrate Lyase (ACLY) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to ATP Citrate Lyase (ACLY) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to ATP Citrate Lyase (ACLY) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for ATP Citrate Lyase (ACLY) CLIA Kit Customized Service Offer
n/a ELISA Kit for ATP Citrate Lyase (ACLY) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant ATP Citrate Lyase (ACLY) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to ATP Citrate Lyase (ACLY) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to ATP Citrate Lyase (ACLY) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for ATP Citrate Lyase (ACLY) CLIA Kit Customized Service Offer
n/a ELISA Kit for ATP Citrate Lyase (ACLY) ELISA Kit Customized Service Offer
  1. "Cloning and expression of a human ATP-citrate lyase cDNA."Eur. J. Biochem. 204:491-499(1992) [PubMed] [Europe PMC] [Abstract]
  2. "Variant cDNA sequences of human ATP:citrate lyase: cloning, expression, and purification from baculovirus-infected insect cells."Protein Expr. Purif. 9:133-141(1997) [PubMed] [Europe PMC] [Abstract]
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  4. "DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage." Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "Phosphorylation of recombinant human ATP:citrate lyase by cAMP-dependent protein kinase abolishes homotropic allosteric regulation of the enzyme by citrate and increases the enzyme activity. Allosteric activation of ATP:citrate lyase by phosphorylated sugars."Biochemistry 39:1169-1179(2000) [PubMed] [Europe PMC] [Abstract]
  7. "Proteomic identification of proteins conjugated to ISG15 in mouse and human cells."Biochem. Biophys. Res. Commun. 336:496-506(2005) [PubMed] [Europe PMC] [Abstract]
  8. "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells."Nat. Biotechnol. 23:94-101(2005) [PubMed] [Europe PMC] [Abstract]
  9. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
  10. "Improved titanium dioxide enrichment of phosphopeptides from HeLa cells and high confident phosphopeptide identification by cross-validation of MS/MS and MS/MS/MS spectra."J. Proteome Res. 6:4150-4162(2007) [PubMed] [Europe PMC] [Abstract]
  11. "Phosphoproteome of resting human platelets."J. Proteome Res. 7:526-534(2008) [PubMed] [Europe PMC] [Abstract]
  12. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
  13. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  14. "Large-scale proteomics analysis of the human kinome."Mol. Cell. Proteomics 8:1751-1764(2009) [PubMed] [Europe PMC] [Abstract]
  15. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  16. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
  17. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  18. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  19. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  20. "Acetylation stabilizes ATP-citrate lyase to promote lipid biosynthesis and tumor growth."Mol. Cell 51:506-518(2013) [PubMed] [Europe PMC] [Abstract]
  21. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  22. "Identification of the citrate-binding site of human ATP-citrate lyase using X-ray crystallography."J. Biol. Chem. 285:27418-27428(2010) [PubMed] [Europe PMC] [Abstract]
  23. "ADP-Mg2+ bound to the ATP-grasp domain of ATP-citrate lyase."Acta Crystallogr. F 67:1168-1172(2011) [PubMed] [Europe PMC] [Abstract]