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V-Abl Abelson Murine Leukemia Viral Oncogene Homolog 2 (ABL2)

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ARG; ABLL; Abelson tyrosine-protein kinase 2; Abelson-related gene protein; Tyrosine-protein kinase ARG

V-Abl Abelson Murine Leukemia Viral Oncogene Homolog 2 (ABL2)
CCC J690
HGNC 77
MGI 87860
PubMed 21417343
RGD 1590898
UniProt P42684
Wiki ABL2
The detection of a novel 12-kb transcript from this gene in human normal and tumor cells established it as a new member of the tyrosine kinase family that is closely related to but distinct from ABL. Kruh et al. (1990) assembled a full-length ARG cDNA by using the partial ARG sequence as probe to screen cDNA libraries prepared from K562, M426, and A172 cells and monocytes. The deduced 1,182-amino acid ARG protein shows high similarity to ABL in overall structural architecture as well as in the sequence of the tyrosine kinase domain and the SH2 and SH3 domains. ARG, like ABL, is expressed as 2 transcripts that result from alternative splicing and encode alternative protein forms that differ only in their N termini and one of which contains a myristoylation site.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant V-Abl Abelson Murine Leukemia Viral Oncogene Homolog 2 (ABL2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to V-Abl Abelson Murine Leukemia Viral Oncogene Homolog 2 (ABL2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to V-Abl Abelson Murine Leukemia Viral Oncogene Homolog 2 (ABL2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for V-Abl Abelson Murine Leukemia Viral Oncogene Homolog 2 (ABL2) CLIA Kit Customized Service Offer
n/a ELISA Kit for V-Abl Abelson Murine Leukemia Viral Oncogene Homolog 2 (ABL2) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant V-Abl Abelson Murine Leukemia Viral Oncogene Homolog 2 (ABL2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to V-Abl Abelson Murine Leukemia Viral Oncogene Homolog 2 (ABL2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to V-Abl Abelson Murine Leukemia Viral Oncogene Homolog 2 (ABL2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for V-Abl Abelson Murine Leukemia Viral Oncogene Homolog 2 (ABL2) CLIA Kit Customized Service Offer
n/a ELISA Kit for V-Abl Abelson Murine Leukemia Viral Oncogene Homolog 2 (ABL2) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant V-Abl Abelson Murine Leukemia Viral Oncogene Homolog 2 (ABL2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to V-Abl Abelson Murine Leukemia Viral Oncogene Homolog 2 (ABL2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to V-Abl Abelson Murine Leukemia Viral Oncogene Homolog 2 (ABL2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for V-Abl Abelson Murine Leukemia Viral Oncogene Homolog 2 (ABL2) CLIA Kit Customized Service Offer
n/a ELISA Kit for V-Abl Abelson Murine Leukemia Viral Oncogene Homolog 2 (ABL2) ELISA Kit Customized Service Offer
  1. "The complete coding sequence of arg defines the Abelson subfamily of cytoplasmic tyrosine kinases."Proc. Natl. Acad. Sci. U.S.A. 87:5802-5806(1990) [PubMed] [Europe PMC] [Abstract]
  2. "Eight full-length abelson related gene (Arg) isoforms are constitutively expressed in caki-1 cell line and cell distribution of two isoforms has been analyzed after transfection."J. Cell. Biochem. 105:1219-1227(2008) [PubMed] [Europe PMC] [Abstract]
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The full-ORF clone resource of the German cDNA consortium."BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
  5. "The DNA sequence and biological annotation of human chromosome 1." Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  7. "A novel human gene closely related to the abl proto-oncogene."Science 234:1545-1548(1986) [PubMed] [Europe PMC] [Abstract]
  8. "Two distinct phosphorylation pathways have additive effects on Abl family kinase activation."Mol. Cell. Biol. 23:3884-3896(2003) [PubMed] [Europe PMC] [Abstract]
  9. "RIN1 is an ABL tyrosine kinase activator and a regulator of epithelial-cell adhesion and migration."Curr. Biol. 15:815-823(2005) [PubMed] [Europe PMC] [Abstract]
  10. "Ubiquitination and degradation of the Arg tyrosine kinase is regulated by oxidative stress."Oncogene 24:2433-2440(2005) [PubMed] [Europe PMC] [Abstract]
  11. "Interaction between c-Abl and Arg tyrosine kinases and proteasome subunit PSMA7 regulates proteasome degradation."Mol. Cell 22:317-327(2006) [PubMed] [Europe PMC] [Abstract]
  12. "A probability-based approach for high-throughput protein phosphorylation analysis and site localization."Nat. Biotechnol. 24:1285-1292(2006) [PubMed] [Europe PMC] [Abstract]
  13. "A critical role for cortactin phosphorylation by Abl-family kinases in PDGF-induced dorsal-wave formation."Curr. Biol. 17:445-451(2007) [PubMed] [Europe PMC] [Abstract]
  14. "ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage."Science 316:1160-1166(2007) [PubMed] [Europe PMC] [Abstract]
  15. "Abl kinases regulate autophagy by promoting the trafficking and function of lysosomal components."J. Biol. Chem. 283:35941-35953(2008) [PubMed] [Europe PMC] [Abstract]
  16. "Regulation of F-actin-dependent processes by the Abl family of tyrosine kinases."J. Cell Sci. 116:2613-2626(2003) [PubMed] [Europe PMC] [Abstract]
  17. "How do Abl family kinases regulate cell shape and movement?"Trends Cell Biol. 14:36-44(2004) [PubMed] [Europe PMC] [Abstract]
  18. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
  19. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  20. "Emerging roles of Abl family tyrosine kinases in microbial pathogenesis."Trends Biochem. Sci. 33:80-90(2008) [PubMed] [Europe PMC] [Abstract]
  21. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
  22. "Large-scale proteomics analysis of the human kinome."Mol. Cell. Proteomics 8:1751-1764(2009) [PubMed] [Europe PMC] [Abstract]
  23. "Unc119 protects from Shigella infection by inhibiting the Abl family kinases."PLoS ONE 4:E5211-E5211(2009) [PubMed] [Europe PMC] [Abstract]
  24. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  25. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  26. "ABL tyrosine kinases: evolution of function, regulation, and specificity."Sci. Signal. 3:RE6-RE6(2010) [PubMed] [Europe PMC] [Abstract]
  27. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  28. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  29. "Solution structure of the human ABL2 SH2 domain."Submitted (FEB-2008) to the PDB data bank
  30. "Crystal structures of ABL-related gene (ABL2) in complex with imatinib, tozasertib (VX-680), and a type I inhibitor of the triazole carbothioamide class."J. Med. Chem. 54:2359-2367(2011) [PubMed] [Europe PMC] [Abstract]
  31. "Lysozyme contamination facilitates crystallization of a heterotrimeric cortactin-Arg-lysozyme complex."Acta Crystallogr. F 68:154-158(2012) [PubMed] [Europe PMC] [Abstract]
  32. "Patterns of somatic mutation in human cancer genomes." Nature 446:153-158(2007) [PubMed] [Europe PMC] [Abstract]