Aminoadipate Semialdehyde Dehydrogenase (AASDH)

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LYS2; ACSF4; Acyl-CoA Synthetase Family Member 4

Aminoadipate Semialdehyde Dehydrogenase (AASDH)
PQQ deprivation in both rats and mice resulted in a decrease in mitochondrial content. In rats, alpha-aminoadipic acid (alphaAA), which is derived from alpha-aminoadipic semialdehyde (alphaAAS) and made from lysine in mitochondria, and the plasma levels of amino acids known to be oxidized in mitochondria were correlated with changes in the liver mitochondrial content of PQQ-deprived rats, but not PQQ-supplemented rats.
In contrast, the levels of NAD dependent alpha-aminoadipate-delta-semialdehyde dehydrogenase (AASDH), a cytosolic enzyme important to alphaAA production from alphaAAS, was not influenced by PQQ dietary status. Moreover, the levels of U26 mRNA were not significantly changed even when diets differed markedly in PQQ and dietary lysine content.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Aminoadipate Semialdehyde Dehydrogenase (AASDH) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Aminoadipate Semialdehyde Dehydrogenase (AASDH) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Aminoadipate Semialdehyde Dehydrogenase (AASDH) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Aminoadipate Semialdehyde Dehydrogenase (AASDH) CLIA Kit Customized Service Offer
n/a ELISA Kit for Aminoadipate Semialdehyde Dehydrogenase (AASDH) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Aminoadipate Semialdehyde Dehydrogenase (AASDH) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Aminoadipate Semialdehyde Dehydrogenase (AASDH) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Aminoadipate Semialdehyde Dehydrogenase (AASDH) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Aminoadipate Semialdehyde Dehydrogenase (AASDH) CLIA Kit Customized Service Offer
n/a ELISA Kit for Aminoadipate Semialdehyde Dehydrogenase (AASDH) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Aminoadipate Semialdehyde Dehydrogenase (AASDH) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Aminoadipate Semialdehyde Dehydrogenase (AASDH) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Aminoadipate Semialdehyde Dehydrogenase (AASDH) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Aminoadipate Semialdehyde Dehydrogenase (AASDH) CLIA Kit Customized Service Offer
n/a ELISA Kit for Aminoadipate Semialdehyde Dehydrogenase (AASDH) ELISA Kit Customized Service Offer
  1. "Cloning and characterization of a novel human homolog of mouse U26, a putative PQQ-dependent AAS dehydrogenase."Mol. Biol. Rep. 32:47-53(2005) [PubMed] [Europe PMC] [Abstract]
  2. "The full-ORF clone resource of the German cDNA consortium."BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
  3. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4." Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells." Genome Res. 10:1546-1560(2000) [PubMed] [Europe PMC] [Abstract]
  6. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]