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Tribbles Homolog 1 (TRIB1)

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GIG2; C8FW; SKIP1; G-protein-coupled receptor-induced gene 2 protein

Tribbles Homolog 1 (TRIB1)
CCC J709
HGNC 16891
MGI 2443397
PubMed 23515163
RGD 621596
UniProt Q96RU8
Wiki TRIB1
TRIB1 is likely to be inactive, since it lacks the active-site lysine within the serine/threonine kinase-like domain. Quantitative real-time PCR of several tissues detected highest TRIB1 expression in skeletal muscle, thyroid, pancreas, peripheral blood leukocytes, and bone marrow.
Overexpression of TRIB1 inhibited oncogenic Ras (HRAS)-driven AP1 activation and MEKK1 (MAP3K1)-mediated AP1 activation. ERK activation was enhanced by TRIB1. Coimmunoprecipitation and yeast 2-hybrid assays showed that MEK1 (MAP2K1) interacted with both TRIB1 and TRIB3, and MKK4 (MAP2K4) interacted specifically with TRIB1. Cotransfection of MKK4 enhanced the level of TRIB1, indicating that the TRIB-MAPKK interaction stabilized TRIB1.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Tribbles Homolog 1 (TRIB1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Tribbles Homolog 1 (TRIB1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Tribbles Homolog 1 (TRIB1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Tribbles Homolog 1 (TRIB1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Tribbles Homolog 1 (TRIB1) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Tribbles Homolog 1 (TRIB1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Tribbles Homolog 1 (TRIB1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Tribbles Homolog 1 (TRIB1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Tribbles Homolog 1 (TRIB1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Tribbles Homolog 1 (TRIB1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Tribbles Homolog 1 (TRIB1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Tribbles Homolog 1 (TRIB1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Tribbles Homolog 1 (TRIB1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Tribbles Homolog 1 (TRIB1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Tribbles Homolog 1 (TRIB1) ELISA Kit Customized Service Offer
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  6. "Characterization of a phosphoprotein whose mRNA is regulated by the mitogenic pathways in dog thyroid cells."Eur. J. Biochem. 248:660-668(1997) [PubMed] [Europe PMC] [Abstract].
  7. "Patterns of somatic mutation in human cancer genomes." Nature 446:153-158(2007) [PubMed] [Europe PMC] [Abstract]