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5-Aminoimidazole-4-Carboxamide Ribonucleotide Formyltransferase (ATIC)

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PURH; AICARFT; IMPCHASE; ATIC; Inosinicase; Phosphoribosylaminoimidazolecarboxamide Formyltransferase/IMP Cyclohydrolase; Inosine monophosphate synthase

5-Aminoimidazole-4-Carboxamide Ribonucleotide Formyltransferase (ATIC)
CCC J722
HGNC 794
MGI 1351352
PubMed 18242762
RGD 70879
UniProt P31939
Wiki ATIC
AICARFT (5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase; EC 2.1.2.3) and IMPCHase (IMP cyclohydrolase; EC 3.5.4.10) catalyze the penultimate and final steps, respectively, of the de novo purine biosynthetic pathway. Both enzymatic activities are present in the same protein, designated ATIC, in all species of prokaryotes and eukaryotes studied by Rayl et al. (1996). The human ATIC cDNA encodes a deduced 591-amino acid protein that is 81% identical to the chicken sequence. Rayl et al. (1996) created truncation mutants of the cDNA and measured their enzymatic properties. In this way they were able to localize the AICARFT activity within the amino-terminal 223 amino acids and the IMPCHase activity to the carboxyl-terminal 406 residues.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant 5-Aminoimidazole-4-Carboxamide Ribonucleotide Formyltransferase (ATIC) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to 5-Aminoimidazole-4-Carboxamide Ribonucleotide Formyltransferase (ATIC) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to 5-Aminoimidazole-4-Carboxamide Ribonucleotide Formyltransferase (ATIC) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for 5-Aminoimidazole-4-Carboxamide Ribonucleotide Formyltransferase (ATIC) CLIA Kit Customized Service Offer
n/a ELISA Kit for 5-Aminoimidazole-4-Carboxamide Ribonucleotide Formyltransferase (ATIC) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant 5-Aminoimidazole-4-Carboxamide Ribonucleotide Formyltransferase (ATIC) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to 5-Aminoimidazole-4-Carboxamide Ribonucleotide Formyltransferase (ATIC) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to 5-Aminoimidazole-4-Carboxamide Ribonucleotide Formyltransferase (ATIC) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for 5-Aminoimidazole-4-Carboxamide Ribonucleotide Formyltransferase (ATIC) CLIA Kit Customized Service Offer
n/a ELISA Kit for 5-Aminoimidazole-4-Carboxamide Ribonucleotide Formyltransferase (ATIC) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant 5-Aminoimidazole-4-Carboxamide Ribonucleotide Formyltransferase (ATIC) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to 5-Aminoimidazole-4-Carboxamide Ribonucleotide Formyltransferase (ATIC) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to 5-Aminoimidazole-4-Carboxamide Ribonucleotide Formyltransferase (ATIC) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for 5-Aminoimidazole-4-Carboxamide Ribonucleotide Formyltransferase (ATIC) CLIA Kit Customized Service Offer
n/a ELISA Kit for 5-Aminoimidazole-4-Carboxamide Ribonucleotide Formyltransferase (ATIC) ELISA Kit Customized Service Offer
  1. "The human purH gene product, 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase. Cloning, sequencing, expression, purification, kinetic analysis, and domain mapping."J. Biol. Chem. 271:2225-2233(1996) [PubMed] [Europe PMC] [Abstract]
  2. "Isolation of human purH gene expressed in the rodent transformant cells by subtractive enrichment of 3'-untranslated region of human transcript."DNA Res. 2:269-275(1995) [PubMed] [Europe PMC] [Abstract]
  3. "Characterization of molecularly cloned human 5-aminoimidazole-4-carboxamide ribonucleotide transformylase."J. Biochem. 122:309-313(1997) [PubMed] [Europe PMC] [Abstract]
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4." Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  7. , Submitted (DEC-2008) to UniProtKB
  8. "Microsequences of 145 proteins recorded in the two-dimensional gel protein database of normal human epidermal keratinocytes."Electrophoresis 13:960-969(1992) [PubMed] [Europe PMC] [Abstract]
  9. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
  10. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
  11. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  12. "N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]
  13. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  14. "Structural insights into the human and avian IMP cyclohydrolase mechanism via crystal structures with the bound XMP inhibitor."Biochemistry 43:1171-1183(2004) [PubMed] [Europe PMC] [Abstract]
  15. "Crystal structures of human bifunctional enzyme aminoimidazole-4-carboxamide ribonucleotide transformylase/IMP cyclohydrolase in complex with potent sulfonyl-containing antifolates."J. Biol. Chem. 279:18034-18045(2004) [PubMed] [Europe PMC] [Abstract]
  16. "AICA-ribosiduria: a novel, neurologically devastating inborn error of purine biosynthesis caused by mutation of ATIC."Am. J. Hum. Genet. 74:1276-1281(2004) [PubMed] [Europe PMC] [Abstract]