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Core Binding Factor Alpha Subunit 2 Translocated To 3 (CBFa2T3)

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ETO2; MTG16; MTGR2; ZMYND4; MTG8-related protein 2; Myeloid translocation gene on chromosome 16 protein; Zinc finger MYND domain-containing protein 4

Core Binding Factor Alpha Subunit 2 Translocated To 3 (CBFa2T3)
CCC J723
HGNC 1537
MGI 1338013
PubMed 23153540
RGD 1310547
UniProt O75081
Wiki CBFA2T3
The t(16;21)(q24;q22) translocation is a rare but recurrent chromosomal abnormality associated with therapy-related myeloid malignancies. The translocation produces a chimeric gene made up of the 5'-region of the AML1 gene fused to the 3'-region of this gene. In addition, CBFA2T3 is a putative breast tumor suppressor. Two transcript variants encoding different isoforms have been found for this gene, and a brefeldin A-sensitive association of RII-alpha protein with one of the isoforms has been demonstrated in the Golgi apparatus.
Widely expressed with higher expression in heart, pancreas, skeletal muscle, spleen, thymus and peripheral blood leukocytes. Expressed in hematopoietic cells (at protein level).

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Core Binding Factor Alpha Subunit 2 Translocated To 3 (CBFa2T3) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Core Binding Factor Alpha Subunit 2 Translocated To 3 (CBFa2T3) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Core Binding Factor Alpha Subunit 2 Translocated To 3 (CBFa2T3) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Core Binding Factor Alpha Subunit 2 Translocated To 3 (CBFa2T3) CLIA Kit Customized Service Offer
n/a ELISA Kit for Core Binding Factor Alpha Subunit 2 Translocated To 3 (CBFa2T3) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Core Binding Factor Alpha Subunit 2 Translocated To 3 (CBFa2T3) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Core Binding Factor Alpha Subunit 2 Translocated To 3 (CBFa2T3) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Core Binding Factor Alpha Subunit 2 Translocated To 3 (CBFa2T3) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Core Binding Factor Alpha Subunit 2 Translocated To 3 (CBFa2T3) CLIA Kit Customized Service Offer
n/a ELISA Kit for Core Binding Factor Alpha Subunit 2 Translocated To 3 (CBFa2T3) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Core Binding Factor Alpha Subunit 2 Translocated To 3 (CBFa2T3) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Core Binding Factor Alpha Subunit 2 Translocated To 3 (CBFa2T3) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Core Binding Factor Alpha Subunit 2 Translocated To 3 (CBFa2T3) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Core Binding Factor Alpha Subunit 2 Translocated To 3 (CBFa2T3) CLIA Kit Customized Service Offer
n/a ELISA Kit for Core Binding Factor Alpha Subunit 2 Translocated To 3 (CBFa2T3) ELISA Kit Customized Service Offer
  1. "The partner gene of AML1 in t(16;21) myeloid malignancies is a novel member of the MTG8(ETO) family."Blood 91:4028-4037(1998) [PubMed] [Europe PMC] [Abstract]
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  3. "CBFA2T1, a gene rearranged in human leukemia, is a member of a multigene family."Genomics 52:332-341(1998) [PubMed] [Europe PMC] [Abstract]
  4. "AML1-MTG16 fusion gene in therapy-related acute leukemia with t(16;21)(q24;q22): two new cases."Leukemia 14:1704-1705(2000) [PubMed] [Europe PMC] [Abstract]
  5. "AML1/MTG16 fusion gene from a t(16;21)(q24;q22) translocation in treatment-induced leukemia after breast cancer."Haematologica 86:212-213(2001) [PubMed] [Europe PMC] [Abstract]
  6. "ETO, a target of t(8;21) in acute leukemia, makes distinct contacts with multiple histone deacetylases and binds mSin3A through its oligomerization domain."Mol. Cell. Biol. 21:6470-6483(2001) [PubMed] [Europe PMC] [Abstract]
  7. "CBFA2T3 (MTG16) is a putative breast tumor suppressor gene from the breast cancer loss of heterozygosity region at 16q24.3."Cancer Res. 62:4599-4604(2002) [PubMed] [Europe PMC] [Abstract]
  8. "Identification and characterization of myeloid translocation gene 16b as a novel a kinase anchoring protein in T lymphocytes."J. Immunol. 168:1590-1599(2002) [PubMed] [Europe PMC] [Abstract]
  9. "The transcriptional corepressor MTG16a contains a novel nucleolar targeting sequence deranged in t(16; 21)-positive myeloid malignancies."Oncogene 21:6703-6712(2002) [PubMed] [Europe PMC] [Abstract]
  10. "AML1-ETO decreases ETO-2 (MTG16) interactions with nuclear receptor corepressor, an effect that impairs granulocyte differentiation."Cancer Res. 64:4547-4554(2004) [PubMed] [Europe PMC] [Abstract]
  11. "A-kinase anchoring proteins interact with phosphodiesterases in T lymphocyte cell lines."J. Immunol. 173:4806-4814(2004) [PubMed] [Europe PMC] [Abstract]
  12. "The leukemia-associated ETO homologues are differently expressed during hematopoietic differentiation."Exp. Hematol. 33:189-198(2005) [PubMed] [Europe PMC] [Abstract]
  13. "ErbB-4 s80 intracellular domain abrogates ETO2-dependent transcriptional repression."J. Biol. Chem. 281:25373-25380(2006) [PubMed] [Europe PMC] [Abstract]
  14. "ZNF652, a novel zinc finger protein, interacts with the putative breast tumor suppressor CBFA2T3 to repress transcription."Mol. Cancer Res. 4:655-665(2006) [PubMed] [Europe PMC] [Abstract]
  15. "The proteomic reactor facilitates the analysis of affinity-purified proteins by mass spectrometry: application for identifying ubiquitinated proteins in human cells."J. Proteome Res. 6:298-305(2007) [PubMed] [Europe PMC] [Abstract]
  16. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  17. "Myeloid translocation gene 16b is a dual A-kinase anchoring protein that interacts selectively with plexins in a phospho-regulated manner."FEBS Lett. 584:873-877(2010) [PubMed] [Europe PMC] [Abstract]
  18. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  19. "The consensus coding sequences of human breast and colorectal cancers." Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract]