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GLI Family Zinc Finger Protein 1 (GLI1)

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Glioma-Associated Oncogene Family Zinc Finger 1

GLI Family Zinc Finger Protein 1 (GLI1)
CCC J729
HGNC 4317
MGI 95727
PubMed 21321483
RGD 621673
UniProt P08151
Wiki GLI1
GLI1 encodes a member of the Kruppel family of zinc finger proteins. The encoded transcription factor is activated by the sonic hedgehog signal transduction cascade and regulates stem cell proliferation. The activity and nuclear localization of this protein is negatively regulated by p53 in an inhibitory loop. Multiple transcript variants encoding different isoforms have been found for this gene.
The zinc fingers contain sequence elements that place the GLI gene product among the Kruppel (Kr) family of zinc finger proteins. (The German word 'Kruppel' means 'cripple' or 'dwarf.') The Drosophila gene is a member of the gap class of segmentation genes; thoracic and anterior abdominal segments fail to form in Kr mutant embryos.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPJ729Hu01 Recombinant GLI Family Zinc Finger Protein 1 (GLI1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAJ729Hu21 Monoclonal Antibody to GLI Family Zinc Finger Protein 1 (GLI1) WB; IHC; ICC; IP.
PAJ729Hu01 Polyclonal Antibody to GLI Family Zinc Finger Protein 1 (GLI1) WB; IHC; ICC; IP.
Assay Kits SEJ729Hu ELISA Kit for GLI Family Zinc Finger Protein 1 (GLI1) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant GLI Family Zinc Finger Protein 1 (GLI1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to GLI Family Zinc Finger Protein 1 (GLI1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to GLI Family Zinc Finger Protein 1 (GLI1) Polyclonal Antibody Customized Service Offer
Assay Kits SEJ729Mu ELISA Kit for GLI Family Zinc Finger Protein 1 (GLI1) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPJ729Ra01 Recombinant GLI Family Zinc Finger Protein 1 (GLI1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAJ729Ra01 Polyclonal Antibody to GLI Family Zinc Finger Protein 1 (GLI1) WB; IHC; ICC; IP.
Assay Kits SEJ729Ra ELISA Kit for GLI Family Zinc Finger Protein 1 (GLI1) Enzyme-linked immunosorbent assay for Antigen Detection.
  1. "The GLI gene is a member of the Kruppel family of zinc finger proteins."Nature 332:371-374(1988) [PubMed] [Europe PMC] [Abstract]
  2. "A novel splice variant of GLI1 that promotes glioblastoma cell migration and invasion."Cancer Res. 69:6790-6798(2009) [PubMed] [Europe PMC] [Abstract]
  3. "The finished DNA sequence of human chromosome 12." Nature 440:346-351(2006) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Gli regulation by the opposing activities of fused and suppressor of fused."Nat. Cell Biol. 2:310-312(2000) [PubMed] [Europe PMC] [Abstract]
  6. "Physical and functional interactions between Zic and Gli proteins."J. Biol. Chem. 276:6889-6892(2001) [PubMed] [Europe PMC] [Abstract]
  7. "Identification of a novel serine/threonine kinase ULK3 as a positive regulator of Hedgehog pathway."Exp. Cell Res. 316:627-637(2010) [PubMed] [Europe PMC] [Abstract]
  8. "Histone deacetylase and Cullin3-REN(KCTD11) ubiquitin ligase interplay regulates Hedgehog signalling through Gli acetylation." Nat. Cell Biol. 12:132-142(2010) [PubMed] [Europe PMC] [Abstract]
  9. "Crystal structure of a five-finger GLI-DNA complex: new perspectives on zinc fingers."Science 261:1701-1707(1993) [PubMed] [Europe PMC] [Abstract]
  10. "Identification of polymorphic variants of the GLI1 oncogene."J. Invest. Dermatol. 115:328-329(2000) [PubMed] [Europe PMC] [Abstract]
  11. "The consensus coding sequences of human breast and colorectal cancers." Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract]