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Ets Variant 4 (ETV4)

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E1A-F; E1AF; PEA3; PEAS3; E1A Enhancer Binding Protein; Adenovirus E1A enhancer-binding protein; Polyomavirus enhancer activator 3 homolog

Ets Variant 4 (ETV4)
CCC J730
HGNC 3493
MGI 99423
PubMed 22075993
RGD 1306524
UniProt P43268
Wiki ETV4
Higashino et al. (1993) cloned a cDNA for a protein that binds to the adenovirus E1A enhancer by screening a HeLa cell expression library with an oligomer for the E1AF DNA sequence. The cDNA encodes a 462-amino acid protein that showed sequence similarity within the ETS domain, a region required for sequence-specific DNA binding by members of the ETS oncogene family. E1AF is about 94% identical to the mouse PEA3 protein (polyomavirus enhancer activator-3). Northern blot analysis detected a 2.5-kb mRNA in HeLa cells whose levels increased during the early phase of adenovirus infection.
E1AF can activate the promoters of various matrix metalloproteinases, genes whose expression is associated with tumor cell invasion and metastasis, by 10 to 20 fold.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Ets Variant 4 (ETV4) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Ets Variant 4 (ETV4) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Ets Variant 4 (ETV4) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Ets Variant 4 (ETV4) CLIA Kit Customized Service Offer
n/a ELISA Kit for Ets Variant 4 (ETV4) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Ets Variant 4 (ETV4) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Ets Variant 4 (ETV4) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Ets Variant 4 (ETV4) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Ets Variant 4 (ETV4) CLIA Kit Customized Service Offer
n/a ELISA Kit for Ets Variant 4 (ETV4) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Ets Variant 4 (ETV4) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Ets Variant 4 (ETV4) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Ets Variant 4 (ETV4) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Ets Variant 4 (ETV4) CLIA Kit Customized Service Offer
n/a ELISA Kit for Ets Variant 4 (ETV4) ELISA Kit Customized Service Offer
  1. "22 genes from chromosome 17q21: cloning, sequencing, and characterization of mutations in breast cancer families and tumors."Genomics 25:256-263(1995) [PubMed] [Europe PMC] [Abstract]
  2. "Genomic organization of the human e1af gene, a member of Ets transcription factors."Gene 240:201-207(1999) [PubMed] [Europe PMC] [Abstract]
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  4. "DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage." Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "Isolation of a cDNA encoding the adenovirus E1A enhancer binding protein: a new human member of the ets oncogene family."Nucleic Acids Res. 21:547-553(1993) [PubMed] [Europe PMC] [Abstract]
  7. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  8. "Extracellular signal-regulated kinase mitogen-activated protein kinase signaling initiates a dynamic interplay between sumoylation and ubiquitination to regulate the activity of the transcriptional activator PEA3."Mol. Cell. Biol. 29:3204-3218(2009) [PubMed] [Europe PMC] [Abstract]