≡

Myeloid/Lymphoid Or Mixed Lineage Leukemia Translocated To 3 (MLLT3)

[Edit]

AF9; YEATS3; ALL1-fused gene from chromosome 9 protein; YEATS domain-containing protein 3

Myeloid/Lymphoid Or Mixed Lineage Leukemia Translocated To 3 (MLLT3)
CCC J743
HGNC 7136
MGI 1917372
PubMed 18371451
RGD 620940
UniProt P42568
Wiki MLLT3
MLLT3 regulates early human erythroid and megakaryocytic cell fate. Through expression profiling of prospectively isolated stem and primitive progenitor cells as well as committed progenitors from cord blood (CB), MLLT3 as a candidate regulator of erythroid/megakaryocytic (E/Meg) lineage decisions. Conversely, forced expression of MLLT3 promotes the output of erythroid and megakaryocytic progenitors, and analysis of MLLT3 mutants suggests that this capacity of MLLT3 depends on its transcriptional regulatory activity. Gene expression and cis-regulatory element analyses reveal crossregulatory interactions between MLLT3 and E/Meg-affiliated transcription factor GATA-1. Taken together, the data identify MLLT3 as a regulator of early erythroid and megakaryocytic cell fate in the human system.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Myeloid/Lymphoid Or Mixed Lineage Leukemia Translocated To 3 (MLLT3) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Myeloid/Lymphoid Or Mixed Lineage Leukemia Translocated To 3 (MLLT3) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Myeloid/Lymphoid Or Mixed Lineage Leukemia Translocated To 3 (MLLT3) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Myeloid/Lymphoid Or Mixed Lineage Leukemia Translocated To 3 (MLLT3) CLIA Kit Customized Service Offer
n/a ELISA Kit for Myeloid/Lymphoid Or Mixed Lineage Leukemia Translocated To 3 (MLLT3) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Myeloid/Lymphoid Or Mixed Lineage Leukemia Translocated To 3 (MLLT3) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Myeloid/Lymphoid Or Mixed Lineage Leukemia Translocated To 3 (MLLT3) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Myeloid/Lymphoid Or Mixed Lineage Leukemia Translocated To 3 (MLLT3) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Myeloid/Lymphoid Or Mixed Lineage Leukemia Translocated To 3 (MLLT3) CLIA Kit Customized Service Offer
n/a ELISA Kit for Myeloid/Lymphoid Or Mixed Lineage Leukemia Translocated To 3 (MLLT3) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Myeloid/Lymphoid Or Mixed Lineage Leukemia Translocated To 3 (MLLT3) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Myeloid/Lymphoid Or Mixed Lineage Leukemia Translocated To 3 (MLLT3) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Myeloid/Lymphoid Or Mixed Lineage Leukemia Translocated To 3 (MLLT3) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Myeloid/Lymphoid Or Mixed Lineage Leukemia Translocated To 3 (MLLT3) CLIA Kit Customized Service Offer
n/a ELISA Kit for Myeloid/Lymphoid Or Mixed Lineage Leukemia Translocated To 3 (MLLT3) ELISA Kit Customized Service Offer
  1. "Genes on chromosomes 4, 9, and 19 involved in 11q23 abnormalities in acute leukemia share sequence homology and/or common motifs."Proc. Natl. Acad. Sci. U.S.A. 90:4631-4635(1993) [PubMed] [Europe PMC] [Abstract]
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  3. "DNA sequence and analysis of human chromosome 9." Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "BCoR, a novel corepressor involved in BCL-6 repression."Genes Dev. 14:1810-1823(2000) [PubMed] [Europe PMC] [Abstract]
  6. "The ENL moiety of the childhood leukemia-associated MLL-ENL oncoprotein recruits human Polycomb 3."Oncogene 20:411-419(2001) [PubMed] [Europe PMC] [Abstract]
  7. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
  8. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  9. "Large-scale proteomics analysis of the human kinome."Mol. Cell. Proteomics 8:1751-1764(2009) [PubMed] [Europe PMC] [Abstract]
  10. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  11. "HIV-1 Tat and host AFF4 recruit two transcription elongation factors into a bifunctional complex for coordinated activation of HIV-1 transcription."Mol. Cell 38:428-438(2010) [PubMed] [Europe PMC] [Abstract]
  12. "AFF4, a component of the ELL/P-TEFb elongation complex and a shared subunit of MLL chimeras, can link transcription elongation to leukemia."Mol. Cell 37:429-437(2010) [PubMed] [Europe PMC] [Abstract]
  13. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  14. "The little elongation complex regulates small nuclear RNA transcription."Mol. Cell 44:954-965(2011) [PubMed] [Europe PMC] [Abstract]
  15. "The super elongation complex (SEC) family in transcriptional control."Nat. Rev. Mol. Cell Biol. 13:543-547(2012) [PubMed] [Europe PMC] [Abstract]
  16. "Human ALKBH4 interacts with proteins associated with transcription."PLoS ONE 7:E49045-E49045(2012) [PubMed] [Europe PMC] [Abstract]
  17. "Leukemia fusion target AF9 is an intrinsically disordered transcriptional regulator that recruits multiple partners via coupled folding and binding."Structure 21:176-183(2013) [PubMed] [Europe PMC] [Abstract]