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Menage A Trois Homolog 1 (MNAT1)

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MAT1; RNF66; CAP35; CDK-Activating Kinase Assembly Factor; CDK7/cyclin-H assembly factor; Cyclin-G1-interacting protein; RING finger protein 66

Menage A Trois Homolog 1 (MNAT1)
CCC J744
HGNC 7181
MGI 106207
PubMed 12888564
RGD 628874
UniProt P51948
Wiki MNAT1
Cyclin-dependent kinases (CDKs), which play an essential role in cell cycle control of eukaryotic cells, are phosphorylated and thus activated by the CDK-activating kinase (CAK). CAK is a multisubunit protein that includes CDK7, cyclin H (CCNH), and MAT1. MAT1 is involved in the assembly of the CAK complex.
The cDNA encoded a 309-amino acid polypeptide with a relative mass of 35.8 kD. The human MAT1 amino acid sequence shares 95%, 79%, and 51% identity with sequences of mouse, frog, and starfish Mat1, respectively. Within the zinc-binding RING finger region, the sequences of all 4 species are nearly identical. Northern blot analysis revealed that the human MAT1 gene expressed varied levels of a 1.6-kb transcript in many tissues and cell lines.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Menage A Trois Homolog 1 (MNAT1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Menage A Trois Homolog 1 (MNAT1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Menage A Trois Homolog 1 (MNAT1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Menage A Trois Homolog 1 (MNAT1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Menage A Trois Homolog 1 (MNAT1) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Menage A Trois Homolog 1 (MNAT1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Menage A Trois Homolog 1 (MNAT1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Menage A Trois Homolog 1 (MNAT1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Menage A Trois Homolog 1 (MNAT1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Menage A Trois Homolog 1 (MNAT1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Menage A Trois Homolog 1 (MNAT1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Menage A Trois Homolog 1 (MNAT1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Menage A Trois Homolog 1 (MNAT1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Menage A Trois Homolog 1 (MNAT1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Menage A Trois Homolog 1 (MNAT1) ELISA Kit Customized Service Offer
  1. "In vitro assembly of a functional human CDK7-cyclin H complex requires MAT1, a novel 36 kDa RING finger protein."EMBO J. 14:5608-5617(1995) [PubMed] [Europe PMC] [Abstract]
  2. "Molecular cloning of CDK7-associated human MAT1, a cyclin-dependent kinase-activating kinase (CAK) assembly factor."Cancer Res. 55:6058-6062(1995) [PubMed] [Europe PMC] [Abstract]
  3. "The DNA sequence and analysis of human chromosome 14." Nature 421:601-607(2003) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Immunoaffinity purification and functional characterization of human transcription factor IIH and RNA polymerase II from clonal cell lines that conditionally express epitope-tagged subunits of the multiprotein complexes."J. Biol. Chem. 273:34444-34453(1998) [PubMed] [Europe PMC] [Abstract]
  6. "Reconstitution of the transcription factor TFIIH: assignment of functions for the three enzymatic subunits, XPB, XPD, and cdk7."Mol. Cell 3:87-95(1999) [PubMed] [Europe PMC] [Abstract]
  7. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
  8. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
  9. "Large-scale proteomics analysis of the human kinome."Mol. Cell. Proteomics 8:1751-1764(2009) [PubMed] [Europe PMC] [Abstract]
  10. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  11. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  12. "Solution structure of the N-terminal domain of the human TFIIH MAT1 subunit: new insights into the RING finger family."J. Biol. Chem. 276:7457-7464(2001) [PubMed] [Europe PMC] [Abstract]