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RAD51 Like Protein 1 (RAD51L1)

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R51H2; RAD51B; REC2; hREC2; DNA repair protein RAD51 homolog 2

RAD51 Like Protein 1 (RAD51L1)
CCC J752
HGNC 9822
MGI 1099436
PubMed 20610542
RGD 1560681
UniProt O15315
Wiki RAD51L1
RAD51 Like Protein 1 is a member of the RAD51 protein family. RAD51 family members are evolutionarily conserved proteins essential for DNA repair by homologous recombination. This protein has been shown to form a stable heterodimer with the family member RAD51C, which further interacts with the other family members, such as RAD51, XRCC2, and XRCC3. Overexpression of this gene was found to cause cell cycle G1 delay and cell apoptosis, which suggested a role of this protein in sensing DNA damage. At least three alternatively spliced transcript variants encoding distinct isoforms have been observed.Expressed in a wide range of tissues.The predicted 350-amino acid human protein, designated RAD51B by them, shares 27 to 30% sequence identity with yeast and chicken RAD51 and human RAD51A.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant RAD51 Like Protein 1 (RAD51L1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to RAD51 Like Protein 1 (RAD51L1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to RAD51 Like Protein 1 (RAD51L1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for RAD51 Like Protein 1 (RAD51L1) CLIA Kit Customized Service Offer
n/a ELISA Kit for RAD51 Like Protein 1 (RAD51L1) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant RAD51 Like Protein 1 (RAD51L1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to RAD51 Like Protein 1 (RAD51L1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to RAD51 Like Protein 1 (RAD51L1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for RAD51 Like Protein 1 (RAD51L1) CLIA Kit Customized Service Offer
n/a ELISA Kit for RAD51 Like Protein 1 (RAD51L1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant RAD51 Like Protein 1 (RAD51L1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to RAD51 Like Protein 1 (RAD51L1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to RAD51 Like Protein 1 (RAD51L1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for RAD51 Like Protein 1 (RAD51L1) CLIA Kit Customized Service Offer
n/a ELISA Kit for RAD51 Like Protein 1 (RAD51L1) ELISA Kit Customized Service Offer
  1. "Isolation of human and mouse genes based on homology to REC2, a recombinational repair gene from the fungus Ustilago maydis."Proc. Natl. Acad. Sci. U.S.A. 94:7417-7422(1997) [PubMed] [Europe PMC] [Abstract]
  2. "Identification of a novel human RAD51 homolog, RAD51B."Genomics 46:476-479(1997) [PubMed] [Europe PMC] [Abstract]
  3. "Isolation of novel human and mouse genes of the recA/RAD51 recombination-repair gene family."Nucleic Acids Res. 26:1653-1659(1998) [PubMed] [Europe PMC] [Abstract]
  4. "The DNA sequence and analysis of human chromosome 14." Nature 421:601-607(2003) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "Fusion transcripts involving HMGA2 are not a common molecular mechanism in uterine leiomyomata with rearrangements in 12q15."Cancer Res. 63:1351-1358(2003) [PubMed] [Europe PMC] [Abstract]
  7. "Identification and purification of two distinct complexes containing the five RAD51 paralogs."Genes Dev. 15:3296-3307(2001) [PubMed] [Europe PMC] [Abstract]
  8. "Mediator function of the human Rad51B-Rad51C complex in Rad51/RPA-catalyzed DNA strand exchange."Genes Dev. 15:3308-3318(2001) [PubMed] [Europe PMC] [Abstract]
  9. "Involvement of Rad51C in two distinct protein complexes of Rad51 paralogs in human cells."Nucleic Acids Res. 30:1009-1015(2002) [PubMed] [Europe PMC] [Abstract]
  10. "RAD51C interacts with RAD51B and is central to a larger protein complex in vivo exclusive of RAD51."J. Biol. Chem. 277:8406-8411(2002) [PubMed] [Europe PMC] [Abstract]
  11. "Interactions involving the Rad51 paralogs Rad51C and XRCC3 in human cells."Nucleic Acids Res. 30:1001-1008(2002) [PubMed] [Europe PMC] [Abstract]
  12. "Complex formation by the human Rad51B and Rad51C DNA repair proteins and their activities in vitro."J. Biol. Chem. 278:2469-2478(2003) [PubMed] [Europe PMC] [Abstract]
  13. "Allelic knockout of novel splice variants of human recombination repair gene RAD51B in t(12;14) uterine leiomyomas."Cancer Res. 59:19-23(1999) [PubMed] [Europe PMC] [Abstract]
  14. "Intragenic breakpoint within RAD51L1 in a t(6;14)(p21.3;q24) of a pulmonary chondroid hamartoma."Cytogenet. Cell Genet. 95:17-19(2001) [PubMed] [Europe PMC] [Abstract]
  15. "Holliday junction binding activity of the human Rad51B protein."J. Biol. Chem. 278:2767-2772(2003) [PubMed] [Europe PMC] [Abstract]
  16. "Domain mapping of the Rad51 paralog protein complexes."Nucleic Acids Res. 32:169-178(2004) [PubMed] [Europe PMC] [Abstract]
  17. "BCR/ABL kinase interacts with and phosphorylates the RAD51 paralog, RAD51B."Leukemia 23:2308-2310(2009) [PubMed] [Europe PMC] [Abstract]
  18. "hSWS1.SWSAP1 is an evolutionarily conserved complex required for efficient homologous recombination repair."J. Biol. Chem. 286:41758-41766(2011) [PubMed] [Europe PMC] [Abstract]
  19. "The RAD51 paralogs ensure cellular protection against mitotic defects and aneuploidy."J. Cell Sci. 126:348-359(2013) [PubMed] [Europe PMC] [Abstract]
  20. "Rad51 paralog complexes BCDX2 and CX3 act at different stages in the BRCA1-BRCA2-dependent homologous recombination pathway."Mol. Cell. Biol. 33:387-395(2013) [PubMed] [Europe PMC] [Abstract]
  21. "Ring-shaped Rad51 paralog protein complexes bind Holliday junctions and replication forks as visualized by electron microscopy."J. Biol. Chem. 285:13349-13356(2010) [PubMed] [Europe PMC] [Abstract]