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SH3 Domain GRB2 Like Protein 1 (SH3GL1)

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CNSA1; EEN; SH3D2B; SH3P8; Endophilin-A2; Extra eleven-nineteen leukemia fusion gene protein; EEN fusion partner of MLL; Fusion Partner of MLL; SH3-Containing Protein EEN

SH3 Domain GRB2 Like Protein 1 (SH3GL1)
CCC J758
HGNC 10830
MGI 700010
PubMed 23970061
UniProt Q99961
Wiki SH3GL1
As all characterized MLL fusion genes previously identified had been shown to retain the derivative chromosome 11, the 3-prime RACE (rapid amplification of cDNA ends) method was chosen to isolate the fusion partner of MLL in the patient's leukemic cells. The deduced EEN protein of 368 amino acids contains a central alpha-helical region and a C-terminal Src homology 3 (SH3) domain most similar to the C-terminal SH3 domain found in the GRB2 family of genes.
EEN was expressed in a variety of tissue types and encoded a protein of approximately 46 kD. The EEN protein is the human homolog of a member of a recently described murine SH3 domain-containing protein family. It is also highly related to a putative gene identified in C. elegans.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant SH3 Domain GRB2 Like Protein 1 (SH3GL1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to SH3 Domain GRB2 Like Protein 1 (SH3GL1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to SH3 Domain GRB2 Like Protein 1 (SH3GL1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for SH3 Domain GRB2 Like Protein 1 (SH3GL1) CLIA Kit Customized Service Offer
n/a ELISA Kit for SH3 Domain GRB2 Like Protein 1 (SH3GL1) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant SH3 Domain GRB2 Like Protein 1 (SH3GL1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to SH3 Domain GRB2 Like Protein 1 (SH3GL1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to SH3 Domain GRB2 Like Protein 1 (SH3GL1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for SH3 Domain GRB2 Like Protein 1 (SH3GL1) CLIA Kit Customized Service Offer
n/a ELISA Kit for SH3 Domain GRB2 Like Protein 1 (SH3GL1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant SH3 Domain GRB2 Like Protein 1 (SH3GL1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to SH3 Domain GRB2 Like Protein 1 (SH3GL1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to SH3 Domain GRB2 Like Protein 1 (SH3GL1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for SH3 Domain GRB2 Like Protein 1 (SH3GL1) CLIA Kit Customized Service Offer
n/a ELISA Kit for SH3 Domain GRB2 Like Protein 1 (SH3GL1) ELISA Kit Customized Service Offer
  1. "A novel SH3-containing human gene family preferentially expressed in the central nervous system."Genomics 41:427-434(1997) [PubMed] [Europe PMC] [Abstract]
  2. "EEN encodes for a member of a new family of proteins containing an Src homology 3 domain and is the third gene located on chromosome 19p13 that fuses to MLL in human leukemia."Proc. Natl. Acad. Sci. U.S.A. 94:2563-2568(1997) [PubMed] [Europe PMC] [Abstract]
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The DNA sequence and biology of human chromosome 19." Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "The SH3 domains of endophilin and amphiphysin bind to the proline-rich region of synaptojanin 1 at distinct sites that display an unconventional binding specificity."J. Biol. Chem. 274:32001-32007(1999) [PubMed] [Europe PMC] [Abstract]
  7. "Structural and biochemical studies of ALIX/AIP1 and its role in retrovirus budding."Cell 128:841-852(2007) [PubMed] [Europe PMC] [Abstract]
  8. "Phosphoproteome of resting human platelets."J. Proteome Res. 7:526-534(2008) [PubMed] [Europe PMC] [Abstract]
  9. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  10. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
  11. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  12. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  13. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  14. "Bin2 is a membrane sculpting N-BAR protein that influences leucocyte podosomes, motility and phagocytosis."PLoS ONE 7:E52401-E52401(2012) [PubMed] [Europe PMC] [Abstract]
  15. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]