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Synovial Sarcoma, X Breakpoint 2 (SSX2)

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HD21; HOM-MEL-40; SSX2B; Sarcoma,Synovial,X-Chromosome-Related 2; Cancer/Testis Antigen Family 5,Member 2a; Tumor antigen HOM-MEL-40

Synovial Sarcoma, X Breakpoint 2 (SSX2)
CCC J760
HGNC 11336
PubMed 22797074
UniProt Q16385
Wiki SSX2
SSX2 belongs to the family of highly homologous synovial sarcoma X (SSX) breakpoint proteins. These proteins may function as transcriptional repressors. They are also capable of eliciting spontaneously humoral and cellular immune responses in cancer patients, and are potentially useful targets in cancer vaccine-based immunotherapy. SSX1, SSX2 and SSX4 genes have been involved in the t(X;18) translocation characteristically found in all synovial sarcomas. This translocation results in the fusion of the synovial sarcoma translocation gene on chromosome 18 to one of the SSX genes on chromosome X. The encoded hybrid proteins are probably responsible for transforming activity. Two transcript variants encoding distinct isoforms have been identified for this gene.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Synovial Sarcoma, X Breakpoint 2 (SSX2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Synovial Sarcoma, X Breakpoint 2 (SSX2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Synovial Sarcoma, X Breakpoint 2 (SSX2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Synovial Sarcoma, X Breakpoint 2 (SSX2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Synovial Sarcoma, X Breakpoint 2 (SSX2) ELISA Kit Customized Service Offer
  1. "Fusion of SYT to two genes, SSX1 and SSX2, encoding proteins with homology to the Kruppel-associated box in human synovial sarcoma."EMBO J. 14:2333-2340(1995) [PubMed] [Europe PMC] [Abstract]
  2. "The DNA sequence of the human X chromosome." Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  4. "Identification of two alternative fusion genes, SYT-SSX1 and SYT-SSX2, in t(X;18)(p11.2;q11.2)-positive synovial sarcomas."Hum. Mol. Genet. 4:1097-1099(1995) [PubMed] [Europe PMC] [Abstract]
  5. "Identification of novel genes, SYT and SSX, involved in the t(X;18)(p11.2;q11.2) translocation found in human synovial sarcoma."Nat. Genet. 7:502-508(1994) [PubMed] [Europe PMC] [Abstract]
  6. "Molecular diagnosis of synovial sarcoma and characterization of a variant SYT-SSX2 fusion transcript."Am. J. Pathol. 147:1592-1599(1995) [PubMed] [Europe PMC] [Abstract]
  7. "The cancer-related protein SSX2 interacts with the human homologue of a Ras-like GTPase interactor, RAB3IP, and a novel nuclear protein, SSX2IP."Genes Chromosomes Cancer 34:285-298(2002) [PubMed] [Europe PMC] [Abstract]