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Synovial Sarcoma, X Breakpoint 1 (SSX1)

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SSRC; CT5.1; Cancer/Testis Antigen Family 5,Member 1

Synovial Sarcoma, X Breakpoint 1 (SSX1)
CCC J761
HGNC 11335
MGI 2446771
PubMed 21454665
RGD 1593374
UniProt Q16384
Wiki SSX1
SSX1 belongs to the family of highly homologous synovial sarcoma X (SSX) breakpoint proteins. They are also capable of eliciting spontaneously humoral and cellular immune responses in cancer patients, and are potentially useful targets in cancer vaccine-based immunotherapy.This translocation results in the fusion of the synovial sarcoma translocation gene on chromosome 18 to one of the SSX genes on chromosome X.
The encoded hybrid proteins are probably responsible for transforming activity.Expressed at high level in the testis. Expressed at low level in thyroid. Not detected in tonsil, colon, lung, spleen, prostate, kidney, striated and smooth muscles. Detected in rhabdomyosarcoma and fibrosarcoma cell lines. Not detected in mesenchymal and epithelial cell lines.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Synovial Sarcoma, X Breakpoint 1 (SSX1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Synovial Sarcoma, X Breakpoint 1 (SSX1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Synovial Sarcoma, X Breakpoint 1 (SSX1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Synovial Sarcoma, X Breakpoint 1 (SSX1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Synovial Sarcoma, X Breakpoint 1 (SSX1) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Synovial Sarcoma, X Breakpoint 1 (SSX1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Synovial Sarcoma, X Breakpoint 1 (SSX1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Synovial Sarcoma, X Breakpoint 1 (SSX1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Synovial Sarcoma, X Breakpoint 1 (SSX1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Synovial Sarcoma, X Breakpoint 1 (SSX1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Synovial Sarcoma, X Breakpoint 1 (SSX1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Synovial Sarcoma, X Breakpoint 1 (SSX1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Synovial Sarcoma, X Breakpoint 1 (SSX1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Synovial Sarcoma, X Breakpoint 1 (SSX1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Synovial Sarcoma, X Breakpoint 1 (SSX1) ELISA Kit Customized Service Offer
  1. "Fusion of SYT to two genes, SSX1 and SSX2, encoding proteins with homology to the Kruppel-associated box in human synovial sarcoma."EMBO J. 14:2333-2340(1995) [PubMed] [Europe PMC] [Abstract]
  2. "The DNA sequence of the human X chromosome." Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  4. "Identification of two alternative fusion genes, SYT-SSX1 and SYT-SSX2, in t(X;18)(p11.2;q11.2)-positive synovial sarcomas."Hum. Mol. Genet. 4:1097-1099(1995) [PubMed] [Europe PMC] [Abstract]