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Zinc Finger, MYM-Type Protein 2 (ZMYM2)

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FIM; MYM; RAMP; SCLL; ZNF198; Rearranged In An Atypical Myeloproliferative Disorder; Zinc finger protein 198; Fused in myeloproliferative disorders protein

Zinc Finger, MYM-Type Protein 2 (ZMYM2)
CCC J766
HGNC 12989
MGI 1923257
PubMed 23594707
RGD 1593255
UniProt Q9UBW7
Wiki ZMYM2
These translocations were associated with aberrant transcripts in which 4 predicted zinc finger domains, contributed by the widely expressed chromosome 13 gene ZNF198, were fused to the FGFR1 tyrosine-kinase domain. Transient expression studies showed that the ZNF198-FGFR1 fusion transcript directed the synthesis of an approximately 87-kD polypeptide, localizing predominantly to the cytoplasm.
The novel sequence that was fused to FGFR1, comprising the 5-prime end of the fusion transcript, was mapped to chromosome 13 with the CEPH mega-YAC library and the Genebridge 4 radiation hybrid panel. The findings were consistent with the pericentromeric 13q11-q12 assignments for the t(8;13) cytogenetic breakpoints.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Zinc Finger, MYM-Type Protein 2 (ZMYM2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Zinc Finger, MYM-Type Protein 2 (ZMYM2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Zinc Finger, MYM-Type Protein 2 (ZMYM2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Zinc Finger, MYM-Type Protein 2 (ZMYM2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Zinc Finger, MYM-Type Protein 2 (ZMYM2) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Zinc Finger, MYM-Type Protein 2 (ZMYM2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Zinc Finger, MYM-Type Protein 2 (ZMYM2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Zinc Finger, MYM-Type Protein 2 (ZMYM2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Zinc Finger, MYM-Type Protein 2 (ZMYM2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Zinc Finger, MYM-Type Protein 2 (ZMYM2) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Zinc Finger, MYM-Type Protein 2 (ZMYM2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Zinc Finger, MYM-Type Protein 2 (ZMYM2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Zinc Finger, MYM-Type Protein 2 (ZMYM2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Zinc Finger, MYM-Type Protein 2 (ZMYM2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Zinc Finger, MYM-Type Protein 2 (ZMYM2) ELISA Kit Customized Service Offer
  1. "Fibroblast growth factor receptor 1 is fused to FIM in stem-cell myeloproliferative disorder with t(8;13)(p12;q12)."Proc. Natl. Acad. Sci. U.S.A. 95:5712-5717(1998) [PubMed] [Europe PMC] [Abstract]
  2. "Consistent fusion of ZNF198 to the fibroblast growth factor receptor-1 in the t(8;13)(p11;q12) myeloproliferative syndrome."Blood 92:1735-1742(1998) [PubMed] [Europe PMC] [Abstract]
  3. "The genomic structure of ZNF198 and location of breakpoints in the t(8;13) myeloproliferative syndrome."Genomics 55:118-121(1999) [PubMed] [Europe PMC] [Abstract]
  4. "Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs." Genome Res. 11:422-435(2001) [PubMed] [Europe PMC] [Abstract]
  5. "The full-ORF clone resource of the German cDNA consortium."BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
  6. "The DNA sequence and analysis of human chromosome 13." Nature 428:522-528(2004) [PubMed] [Europe PMC] [Abstract]
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  8. "The t(8;13) atypical myeloproliferative disorder: further analysis of the ZNF198 gene and lack of evidence for multiple genes disrupted on chromosome 13."Blood 92:1456-1458(1998) [PubMed] [Europe PMC] [Abstract]
  9. "The t(8;13)(p11;q11-12) rearrangement associated with an atypical myeloproliferative disorder fuses the fibroblast growth factor receptor 1 gene to a novel gene RAMP."Hum. Mol. Genet. 7:637-642(1998) [PubMed] [Europe PMC] [Abstract]
  10. "FGFR1 is fused with a novel zinc-finger gene, ZNF198, in the t(8;13) leukaemia/lymphoma syndrome."Nat. Genet. 18:84-87(1998) [PubMed] [Europe PMC] [Abstract]
  11. "A candidate X-linked mental retardation gene is a component of a new family of histone deacetylase-containing complexes."J. Biol. Chem. 278:7234-7239(2003) [PubMed] [Europe PMC] [Abstract]
  12. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  13. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
  14. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  15. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  16. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  17. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]