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Transcription Factor B2, Mitochondrial (TFB2M)

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Hkp1; NS5ATP5; Dimethyladenosine Transferase 2,Mitochondrial; S-adenosylmethionine-6-N', N'-adenosyl(rRNA) dimethyltransferase 2; Hepatitis C virus NS5A-transactivated 5

Transcription Factor B2, Mitochondrial (TFB2M)
CCC J773
HGNC 18559
MGI 107937
PubMed 15684387
RGD 1307091
UniProt Q9H5Q4
Wiki TFB2M
TFB2M shares 53% amino acid identity with its mouse homolog, but only 25% identity with TFB1M across a conserved region, suggesting a gene duplication event early in metozoan evolution. Northern blot analysis showed that TFB1M and TFB2M are expressed ubiquitously. Both TFB1M and TFB2M independently supported promoter-specific mtDNA transcription in a pure recombinant in vitro system containing mitochondrial RNA polymerase (POLRMT) and mitochondrial transcription factor A (TFAM); however, TFB2M was at least 1 order of magnitude more active in promoting transcription than TFB1M. Both factors are highly homologous to bacterial rRNA dimethyltransferases, which suggests that an RNA-modifying enzyme was recruited during evolution to function as a mitochondrial transcription factor.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Transcription Factor B2, Mitochondrial (TFB2M) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Transcription Factor B2, Mitochondrial (TFB2M) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Transcription Factor B2, Mitochondrial (TFB2M) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Transcription Factor B2, Mitochondrial (TFB2M) CLIA Kit Customized Service Offer
n/a ELISA Kit for Transcription Factor B2, Mitochondrial (TFB2M) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Transcription Factor B2, Mitochondrial (TFB2M) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Transcription Factor B2, Mitochondrial (TFB2M) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Transcription Factor B2, Mitochondrial (TFB2M) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Transcription Factor B2, Mitochondrial (TFB2M) CLIA Kit Customized Service Offer
n/a ELISA Kit for Transcription Factor B2, Mitochondrial (TFB2M) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Transcription Factor B2, Mitochondrial (TFB2M) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Transcription Factor B2, Mitochondrial (TFB2M) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Transcription Factor B2, Mitochondrial (TFB2M) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Transcription Factor B2, Mitochondrial (TFB2M) CLIA Kit Customized Service Offer
n/a ELISA Kit for Transcription Factor B2, Mitochondrial (TFB2M) ELISA Kit Customized Service Offer
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  2. "The DNA sequence and biological annotation of human chromosome 1." Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  4. "Mitochondrial transcription factors B1 and B2 activate transcription of human mtDNA."Nat. Genet. 31:289-294(2002) [PubMed] [Europe PMC] [Abstract]
  5. "Human mitochondrial transcription factor B1 interacts with the C-terminal activation region of h-mtTFA and stimulates transcription independently of its RNA methyltransferase activity."Mol. Cell. Biol. 23:5816-5824(2003) [PubMed] [Europe PMC] [Abstract]
  6. "The mitochondrial RNA polymerase contributes critically to promoter specificity in mammalian cells."EMBO J. 23:4606-4614(2004) [PubMed] [Europe PMC] [Abstract]
  7. "Control of mitochondrial transcription specificity factors (TFB1M and TFB2M) by nuclear respiratory factors (NRF-1 and NRF-2) and PGC-1 family coactivators."Mol. Cell. Biol. 25:1354-1366(2005) [PubMed] [Europe PMC] [Abstract]
  8. "Evidence for an early gene duplication event in the evolution of the mitochondrial transcription factor B family and maintenance of rRNA methyltransferase activity in human mtTFB1 and mtTFB2."J. Mol. Evol. 63:707-717(2006) [PubMed] [Europe PMC] [Abstract]
  9. "Human mitochondrial transcription revisited: only TFAM and TFB2M are required for transcription of the mitochondrial genes in vitro."J. Biol. Chem. 285:18129-18133(2010) [PubMed] [Europe PMC] [Abstract]
  10. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  11. "Mitochondrial transcription factors TFA, TFB1 and TFB2: a search for DNA variants/haplotypes and the risk of cardiac hypertrophy."Dis. Markers 25:131-139(2008) [PubMed] [Europe PMC] [Abstract]
  12. "Mutational screening of the mitochondrial transcription factors B1 and B2 (TFB1M and TFB2M) in Parkinson's disease."Parkinsonism Relat. Disord. 15:468-470(2009) [PubMed] [Europe PMC] [Abstract]