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HLA-B Associated Transcript 1 (BAT1)

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DDX39B; UAP56; DEAD(Asp-Glu-Ala-Asp)Box Polypeptide 39B; 56 kDa U2AF65-associated protein; HLA-B-associated transcript 1 protein; ATP-dependent RNA helicase p47

HLA-B Associated Transcript 1 (BAT1)
CCC J775
HGNC 13917
MGI 99240
PubMed 22071774
RGD 70923
UniProt Q13838
Wiki BAT1
BAT1 encodes a member of the DEAD box family of RNA-dependent ATPases that mediate ATP hydrolysis during pre-mRNA splicing. The encoded protein is an essential splicing factor required for association of U2 small nuclear ribonucleoprotein with pre-mRNA, and also plays an important role in mRNA export from the nucleus to the cytoplasm. A cluster of genes, BAT1-BAT5, is localized in the vicinity of the genes for TNF alpha and TNF beta. These genes are all within the human major histocompatibility complex class III region.
Mutations in this gene may be associated with rheumatoid arthritis. Alternatively spliced transcript variants encoding the same protein have been described.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPJ775Hu01 Recombinant HLA-B Associated Transcript 1 (BAT1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies n/a Monoclonal Antibody to HLA-B Associated Transcript 1 (BAT1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to HLA-B Associated Transcript 1 (BAT1) Polyclonal Antibody Customized Service Offer
Assay Kits SEJ775Hu ELISA Kit for HLA-B Associated Transcript 1 (BAT1) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant HLA-B Associated Transcript 1 (BAT1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to HLA-B Associated Transcript 1 (BAT1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to HLA-B Associated Transcript 1 (BAT1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for HLA-B Associated Transcript 1 (BAT1) CLIA Kit Customized Service Offer
n/a ELISA Kit for HLA-B Associated Transcript 1 (BAT1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant HLA-B Associated Transcript 1 (BAT1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to HLA-B Associated Transcript 1 (BAT1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to HLA-B Associated Transcript 1 (BAT1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for HLA-B Associated Transcript 1 (BAT1) CLIA Kit Customized Service Offer
n/a ELISA Kit for HLA-B Associated Transcript 1 (BAT1) ELISA Kit Customized Service Offer
  1. "The BAT1 gene in the MHC encodes an evolutionarily conserved putative nuclear RNA helicase of the DEAD family."Genomics 26:210-218(1995) [PubMed] [Europe PMC] [Abstract]
  2. "Rapid evolution of major histocompatibility complex class I genes in primates generates new disease alleles in humans via hitchhiking diversity." Genetics 173:1555-1570(2006) [PubMed] [Europe PMC] [Abstract]
  3. "The DNA sequence and analysis of human chromosome 6." Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "U2AF65 recruits a novel human DEAD box protein required for the U2 snRNP-branchpoint interaction."Genes Dev. 11:1864-1872(1997) [PubMed] [Europe PMC] [Abstract]
  6. "Pre-mRNA splicing and mRNA export linked by direct interactions between UAP56 and Aly."Nature 413:644-647(2001) [PubMed] [Europe PMC] [Abstract]
  7. "An evolutionarily conserved role for SRm160 in 3'-end processing that functions independently of exon junction complex formation."J. Biol. Chem. 278:44153-44160(2003) [PubMed] [Europe PMC] [Abstract]
  8. "Analysis of a high-throughput yeast two-hybrid system and its use to predict the function of intracellular proteins encoded within the human MHC class III region."Genomics 83:153-167(2004) [PubMed] [Europe PMC] [Abstract]
  9. "Linking transcriptional elongation and messenger RNA export to metastatic breast cancers."Cancer Res. 65:3011-3016(2005) [PubMed] [Europe PMC] [Abstract]
  10. "Recruitment of the human TREX complex to mRNA during splicing."Genes Dev. 19:1512-1517(2005) [PubMed] [Europe PMC] [Abstract]
  11. "Human hHpr1/p84/Thoc1 regulates transcriptional elongation and physically links RNA polymerase II and RNA processing factors."Mol. Cell. Biol. 25:4023-4033(2005) [PubMed] [Europe PMC] [Abstract]
  12. "Human mRNA export machinery recruited to the 5' end of mRNA."Cell 127:1389-1400(2006) [PubMed] [Europe PMC] [Abstract]
  13. "The UL69 transactivator protein of human cytomegalovirus interacts with DEXD/H-Box RNA helicase UAP56 to promote cytoplasmic accumulation of unspliced RNA."Mol. Cell. Biol. 26:1631-1643(2006) [PubMed] [Europe PMC] [Abstract]
  14. "Biochemical characterization of the ATPase and helicase activity of UAP56, an essential pre-mRNA splicing and mRNA export factor."J. Biol. Chem. 282:22544-22550(2007) [PubMed] [Europe PMC] [Abstract]
  15. "ATP-dependent recruitment of export factor Aly/REF onto intronless mRNAs by RNA helicase UAP56."Mol. Cell. Biol. 28:601-608(2008) [PubMed] [Europe PMC] [Abstract]
  16. "Recruitment of the complete hTREX complex is required for Kaposi's sarcoma-associated herpesvirus intronless mRNA nuclear export and virus replication."PLoS Pathog. 4:E1000194-E1000194(2008) [PubMed] [Europe PMC] [Abstract]
  17. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  18. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
  19. "UIF, a new mRNA export adaptor that works together with REF/ALY, requires FACT for recruitment to mRNA."Curr. Biol. 19:1918-1924(2009) [PubMed] [Europe PMC] [Abstract]
  20. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
  21. "ATP is required for interactions between UAP56 and two conserved mRNA export proteins, Aly and CIP29, to assemble the TREX complex."Genes Dev. 24:2043-2053(2010) [PubMed] [Europe PMC] [Abstract]
  22. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  23. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  24. "Interferon-induced antiviral protein MxA interacts with the cellular RNA helicases UAP56 and URH49."J. Biol. Chem. 286:34743-34751(2011) [PubMed] [Europe PMC] [Abstract]
  25. "Genome instability and transcription elongation impairment in human cells depleted of THO/TREX."PLoS Genet. 7:E1002386-E1002386(2011) [PubMed] [Europe PMC] [Abstract]
  26. "Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features."Mol. Cell. Proteomics 11:M111.015131-M111.015131(2012) [PubMed] [Europe PMC] [Abstract]
  27. "The proteins PDIP3 and ZC11A associate with the human TREX complex in an ATP-dependent manner and function in mRNA export."PLoS ONE 7:E43804-E43804(2012) [PubMed] [Europe PMC] [Abstract]
  28. "Chtop is a component of the dynamic TREX mRNA export complex."EMBO J. 32:473-486(2013) [PubMed] [Europe PMC] [Abstract]
  29. "Aly and THO are required for assembly of the human TREX complex and association of TREX components with the spliced mRNA."Nucleic Acids Res. 41:1294-1306(2013) [PubMed] [Europe PMC] [Abstract]
  30. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  31. "Crystal structure of the human ATP-dependent splicing and export factor UAP56."Proc. Natl. Acad. Sci. U.S.A. 101:17628-17633(2004) [PubMed] [Europe PMC] [Abstract]
  32. "Crystal structure of UAP56, a DExD/H-box protein involved in pre-mRNA splicing and mRNA export."Structure 12:1373-1381(2004) [PubMed] [Europe PMC] [Abstract]