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NADH Dehydrogenase Ubiquinone 1 Alpha Subcomplex 4 (NDUFa4)

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MLRQ; CI-9k; CI-MLRQ; Complex I 9kDa Subunit; Cytochrome c oxidase subunit NDUFA4

NADH Dehydrogenase Ubiquinone 1 Alpha Subcomplex 4 (NDUFa4)
CCC J790
HGNC 7687
MGI 107686
PubMed 22902835
RGD 1584719
UniProt O00483
NDUFa4 gene belongs to the complex I 9kDa subunit family. Mammalian complex I of mitochondrial respiratory chain is composed of 45 different subunits. This protein has NADH dehydrogenase activity and oxidoreductase activity. It transfers electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
The deduced 81-amino acid human MLRQ protein has a calculated molecular weight of approximately 9 kD. Human MLRQ shares 88% amino acid identity with bovine and mouse MLRQ. The hydrophobicity profile indicates the presence of a potential membrane-spanning sequence, suggesting that MLRQ is anchored into the inner mitochondrial membrane. The highest expression levels were observed in heart, skeletal muscle, and brain.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant NADH Dehydrogenase Ubiquinone 1 Alpha Subcomplex 4 (NDUFa4) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to NADH Dehydrogenase Ubiquinone 1 Alpha Subcomplex 4 (NDUFa4) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to NADH Dehydrogenase Ubiquinone 1 Alpha Subcomplex 4 (NDUFa4) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for NADH Dehydrogenase Ubiquinone 1 Alpha Subcomplex 4 (NDUFa4) CLIA Kit Customized Service Offer
n/a ELISA Kit for NADH Dehydrogenase Ubiquinone 1 Alpha Subcomplex 4 (NDUFa4) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant NADH Dehydrogenase Ubiquinone 1 Alpha Subcomplex 4 (NDUFa4) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to NADH Dehydrogenase Ubiquinone 1 Alpha Subcomplex 4 (NDUFa4) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to NADH Dehydrogenase Ubiquinone 1 Alpha Subcomplex 4 (NDUFa4) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for NADH Dehydrogenase Ubiquinone 1 Alpha Subcomplex 4 (NDUFa4) CLIA Kit Customized Service Offer
n/a ELISA Kit for NADH Dehydrogenase Ubiquinone 1 Alpha Subcomplex 4 (NDUFa4) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant NADH Dehydrogenase Ubiquinone 1 Alpha Subcomplex 4 (NDUFa4) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to NADH Dehydrogenase Ubiquinone 1 Alpha Subcomplex 4 (NDUFa4) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to NADH Dehydrogenase Ubiquinone 1 Alpha Subcomplex 4 (NDUFa4) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for NADH Dehydrogenase Ubiquinone 1 Alpha Subcomplex 4 (NDUFa4) CLIA Kit Customized Service Offer
n/a ELISA Kit for NADH Dehydrogenase Ubiquinone 1 Alpha Subcomplex 4 (NDUFa4) ELISA Kit Customized Service Offer
  1. "Cloning of the human cDNA sequence encoding the NADH:ubiquinone oxidoreductase MLRQ subunit."Biochem. Mol. Biol. Int. 43:669-675(1997) [PubMed] [Europe PMC] [Abstract]
  2. "Human chromosome 7: DNA sequence and biology." Science 300:767-772(2003) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The subunit composition of the human NADH dehydrogenase obtained by rapid one-step immunopurification."J. Biol. Chem. 278:13619-13622(2003) [PubMed] [Europe PMC] [Abstract]
  5. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  6. "NDUFA4 is a subunit of complex IV of the mammalian electron transport chain."Cell Metab. 16:378-386(2012) [PubMed] [Europe PMC] [Abstract]
  7. "NDUFA4 mutations underlie dysfunction of a cytochrome c oxidase subunit linked to human neurological disease."Cell Rep. 3:1795-1805(2013) [PubMed] [Europe PMC] [Abstract]
  8. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]