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A Disintegrin And Metalloprotease 15 (ADAM15)

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MDC15; Metargidin; Metalloproteinase-like, disintegrin-like, and cysteine-rich protein 15; Metalloprotease RGD disintegrin protein

A Disintegrin And Metalloprotease 15 (ADAM15)
CCC J800
HGNC 193
MGI 1333882
PubMed 11741929
RGD 620402
UniProt Q13444
Wiki ADAM15
The protein encoded by this gene is a member of the ADAM (a disintegrin and metalloproteinase) protein family. ADAM family members are type I transmembrane glycoproteins known to be involved in cell adhesion and proteolytic ectodomain processing of cytokines and adhesion molecules. ADAM15 contains multiple functional domains including a zinc-binding metalloprotease domain, a disintegrin-like domain, as well as an EGF-like domain. Through its disintegrin-like domain, this protein specifically interacts with the integrin beta chain, beta 3. It also interacts with Src family protein-tyrosine kinases in a phosphorylation-dependent manner, suggesting that this protein may function in cell-cell adhesion as well as in cellular signaling. Multiple alternatively spliced transcript variants encoding distinct isoforms have been observed.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPJ800Hu01 Recombinant A Disintegrin And Metalloprotease 15 (ADAM15) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAJ800Hu01 Polyclonal Antibody to A Disintegrin And Metalloprotease 15 (ADAM15) WB; IHC; ICC; IP.
MAJ800Hu21 Monoclonal Antibody to A Disintegrin And Metalloprotease 15 (ADAM15) WB; IHC; ICC; IP.
Assay Kits SEJ800Hu ELISA Kit for A Disintegrin And Metalloprotease 15 (ADAM15) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant A Disintegrin And Metalloprotease 15 (ADAM15) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to A Disintegrin And Metalloprotease 15 (ADAM15) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to A Disintegrin And Metalloprotease 15 (ADAM15) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for A Disintegrin And Metalloprotease 15 (ADAM15) CLIA Kit Customized Service Offer
n/a ELISA Kit for A Disintegrin And Metalloprotease 15 (ADAM15) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant A Disintegrin And Metalloprotease 15 (ADAM15) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to A Disintegrin And Metalloprotease 15 (ADAM15) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to A Disintegrin And Metalloprotease 15 (ADAM15) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for A Disintegrin And Metalloprotease 15 (ADAM15) CLIA Kit Customized Service Offer
n/a ELISA Kit for A Disintegrin And Metalloprotease 15 (ADAM15) ELISA Kit Customized Service Offer
  1. "Metargidin, a membrane-anchored metalloprotease-disintegrin protein with an RGD integrin binding sequence."J. Biol. Chem. 271:4593-4596(1996) [PubMed] [Europe PMC] [Abstract]
  2. "Expression of a disintegrin-like protein in cultured human vascular cells and in vivo."FASEB J. 11:173-180(1997) [PubMed] [Europe PMC] [Abstract]
  3. "ADAM-15 inhibits wound healing in human intestinal epithelial cell monolayers."Am. J. Physiol. 288:G346-G353(2005) [PubMed] [Europe PMC] [Abstract]
  4. "ADAM15 gene structure and differential alternative exon use in human tissues."BMC Mol. Biol. 8:90-90(2007) [PubMed] [Europe PMC] [Abstract]
  5. "Distinct functions of natural ADAM-15 cytoplasmic domain variants in human mammary carcinoma."Mol. Cancer Res. 6:383-394(2008) [PubMed] [Europe PMC] [Abstract]
  6. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  7. "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries." DNA Res. 12:117-126(2005) [PubMed] [Europe PMC] [Abstract]
  8. "The DNA sequence and biological annotation of human chromosome 1." Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
  9. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  10. "Expression of members of a novel membrane linked metalloproteinase family (ADAM) in human articular chondrocytes."Biochem. Biophys. Res. Commun. 230:335-339(1997) [PubMed] [Europe PMC] [Abstract]
  11. "Specific interaction of the recombinant disintegrin-like domain of MDC-15 (metargidin, ADAM-15) with integrin alphavbeta3."J. Biol. Chem. 273:7345-7350(1998) [PubMed] [Europe PMC] [Abstract]
  12. "Interaction of the metalloprotease disintegrins MDC9 and MDC15 with two SH3 domain-containing proteins, endophilin I and SH3PX1."J. Biol. Chem. 274:31693-31699(1999) [PubMed] [Europe PMC] [Abstract]
  13. "Interaction of metargidin (ADAM-15) with alphavbeta3 and alpha5beta1 integrins on different haemopoietic cells."J. Cell Sci. 112:579-587(1999) [PubMed] [Europe PMC] [Abstract]
  14. "ADAM15 is an adherens junction molecule whose surface expression can be driven by VE-cadherin."Exp. Cell Res. 279:239-247(2002) [PubMed] [Europe PMC] [Abstract]
  15. "Phosphorylation-dependent interactions between ADAM15 cytoplasmic domain and Src family protein-tyrosine kinases."J. Biol. Chem. 277:4999-5007(2002) [PubMed] [Europe PMC] [Abstract]
  16. "The role of ADAM 15 in glomerular mesangial cell migration."J. Biol. Chem. 277:33683-33689(2002) [PubMed] [Europe PMC] [Abstract]
  17. "The adaptor protein fish associates with members of the ADAMs family and localizes to podosomes of Src-transformed cells."J. Biol. Chem. 278:16844-16851(2003) [PubMed] [Europe PMC] [Abstract]
  18. "Homeostatic effects of the metalloproteinase disintegrin ADAM15 in degenerative cartilage remodeling."Arthritis Rheum. 52:1100-1109(2005) [PubMed] [Europe PMC] [Abstract]
  19. "Inhibition of airway smooth muscle adhesion and migration by the disintegrin domain of ADAM-15."Am. J. Respir. Cell Mol. Biol. 37:494-500(2007) [PubMed] [Europe PMC] [Abstract]
  20. "ADAM-15/metargidin mediates homotypic aggregation of human T lymphocytes and heterotypic interactions of T lymphocytes with intestinal epithelial cells."J. Biol. Chem. 282:16948-16958(2007) [PubMed] [Europe PMC] [Abstract]
  21. "ADAM15 suppresses cell motility by driving integrin alpha5beta1 cell surface expression via Erk inactivation."Int. J. Biochem. Cell Biol. 40:2164-2173(2008) [PubMed] [Europe PMC] [Abstract]
  22. "The ectodomain shedding of E-cadherin by ADAM15 supports ErbB receptor activation."J. Biol. Chem. 283:18393-18401(2008) [PubMed] [Europe PMC] [Abstract]
  23. "Characterization of the catalytic activity of the membrane-anchored metalloproteinase ADAM15 in cell-based assays."Biochem. J. 420:105-113(2009) [PubMed] [Europe PMC] [Abstract]
  24. "Alternative splicing of ADAM15 regulates its interactions with cellular SH3 proteins."J. Cell. Biochem. 108:877-885(2009) [PubMed] [Europe PMC] [Abstract]