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Zinc Finger Homeobox Protein 1B (ZFHX1B)

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ZEB2; SIP1; SIP-1; SMADIP1; SIP1; Zinc Finger E-Box Binding Homeobox 2; SMAD Interacting Protein 1

Zinc Finger Homeobox Protein 1B (ZFHX1B)
CCC J819
HGNC 14881
MGI 1344407
PubMed 23312518
RGD 1307272
UniProt O60315
Wiki ZFHX1B
The ZEB2 gene is a member of the ZEB1/Drosophila Zfh1 family of 2-handed zinc finger/homeodomain proteins and functions as a DNA-binding transcriptional repressor that interacts with activated SMADs , the transducers of TGF-beta signaling, and interacts with the nucleosome remodeling and histone deacetylation (NURD) complex.
The Smadip1 protein contains a SMAD-binding domain, a homeodomain-like sequence, and 2 separate clusters of zinc fingers, one N-terminal and the other C-terminal.The deduced 1,214-amino acid protein shares significant similarity with rat Zeb1. RT-PCR analysis of human tissues detected highest ZEB2 expression in heart, brain, lung, placenta, and kidney, with moderate expression in ovary, skeletal muscle, liver, and small intestine.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Zinc Finger Homeobox Protein 1B (ZFHX1B) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Zinc Finger Homeobox Protein 1B (ZFHX1B) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Zinc Finger Homeobox Protein 1B (ZFHX1B) Polyclonal Antibody Customized Service Offer
Assay Kits SEJ819Hu ELISA Kit for Zinc Finger Homeobox Protein 1B (ZFHX1B) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPJ819Mu01 Recombinant Zinc Finger Homeobox Protein 1B (ZFHX1B) Positive Control; Immunogen; SDS-PAGE; WB.
RPJ819Mu02 Recombinant Zinc Finger Homeobox Protein 1B (ZFHX1B) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAJ819Mu01 Polyclonal Antibody to Zinc Finger Homeobox Protein 1B (ZFHX1B) WB; IHC; ICC; IP.
PAJ819Mu02 Polyclonal Antibody to Zinc Finger Homeobox Protein 1B (ZFHX1B) WB; IHC; ICC; IP.
Assay Kits SEJ819Mu ELISA Kit for Zinc Finger Homeobox Protein 1B (ZFHX1B) Enzyme-linked immunosorbent assay for Antigen Detection.
SCJ819Mu CLIA Kit for Zinc Finger Homeobox Protein 1B (ZFHX1B) Chemiluminescent immunoassay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Zinc Finger Homeobox Protein 1B (ZFHX1B) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Zinc Finger Homeobox Protein 1B (ZFHX1B) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Zinc Finger Homeobox Protein 1B (ZFHX1B) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Zinc Finger Homeobox Protein 1B (ZFHX1B) CLIA Kit Customized Service Offer
n/a ELISA Kit for Zinc Finger Homeobox Protein 1B (ZFHX1B) ELISA Kit Customized Service Offer
  1. "Loss-of-function mutations in SIP1 Smad interacting protein 1 result in a syndromic Hirschsprung disease."Hum. Mol. Genet. 10:1503-1510(2001) [PubMed] [Europe PMC] [Abstract]
  2. "Mutations in SIP1, encoding Smad interacting protein 1, cause a form of Hirschsprung disease."Nat. Genet. 27:369-370(2001) [PubMed] [Europe PMC] [Abstract]
  3. "Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro."DNA Res. 5:31-39(1998) [PubMed] [Europe PMC] [Abstract]
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  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  7. "Selection system for genes encoding nuclear-targeted proteins."Nat. Biotechnol. 16:1338-1342(1998) [PubMed] [Europe PMC] [Abstract]
  8. "Pc2-mediated sumoylation of Smad-interacting protein 1 attenuates transcriptional repression of E-cadherin."J. Biol. Chem. 280:35477-35489(2005) [PubMed] [Europe PMC] [Abstract]
  9. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
  10. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  11. "Solution structure of the homeobox domain of zinc finger homeobox protein 1B (SMAD interacting protein 1)."Submitted (DEC-2006) to the PDB data bank
  12. "Late infantile Hirschsprung disease-mental retardation syndrome with a 3-bp deletion in ZFHX1B."Neurology 59:1637-1640(2002) [PubMed] [Europe PMC] [Abstract]
  13. "Ocular coloboma and high myopia with Hirschsprung disease associated with a novel ZFHX1B missense mutation and trisomy 21."Am. J. Med. Genet. A 131:86-90(2004) [PubMed] [Europe PMC] [Abstract]
  14. "A missense mutation in the ZFHX1B gene associated with an atypical Mowat-Wilson syndrome phenotype."Am. J. Med. Genet. A 140:1223-1227(2006) [PubMed] [Europe PMC] [Abstract]
  15. "The consensus coding sequences of human breast and colorectal cancers." Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract]