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TRAF Family Member Associated NFKB Activator (TANK)

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TRAF2; I-TRAF; TRAF-interacting protein

TRAF Family Member Associated NFKB Activator (TANK)
CCC J823
HGNC 11562
MGI 107676
PubMed 8710854
RGD 628859
UniProt Q92844
Wiki TANK
The TRAF (tumor necrosis factor receptor-associated factor) family of proteins associate with and transduce signals from members of the tumor necrosis factor receptor superfamily. The protein encoded by this gene is found in the cytoplasm and can bind to TRAF1, TRAF2, or TRAF3, thereby inhibiting TRAF function by sequestering the TRAFs in a latent state in the cytoplasm. For example, the protein encoded by this gene can block TRAF2 binding to LMP1, the Epstein-Barr virus transforming protein, and inhibit LMP1-mediated NF-kappa-B activation. Two transcript variants encoding different isoforms have been found for this gene.TANK is distributed throughout the cytoplasm. In the absence of LMP1, TRAF2 has a similar localization pattern, suggesting that TRAF2 and TANK may colocalize.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPJ823Hu01 Recombinant TRAF Family Member Associated NFKB Activator (TANK) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAJ823Hu01 Polyclonal Antibody to TRAF Family Member Associated NFKB Activator (TANK) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for TRAF Family Member Associated NFKB Activator (TANK) CLIA Kit Customized Service Offer
n/a ELISA Kit for TRAF Family Member Associated NFKB Activator (TANK) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant TRAF Family Member Associated NFKB Activator (TANK) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to TRAF Family Member Associated NFKB Activator (TANK) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to TRAF Family Member Associated NFKB Activator (TANK) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for TRAF Family Member Associated NFKB Activator (TANK) CLIA Kit Customized Service Offer
n/a ELISA Kit for TRAF Family Member Associated NFKB Activator (TANK) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant TRAF Family Member Associated NFKB Activator (TANK) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to TRAF Family Member Associated NFKB Activator (TANK) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to TRAF Family Member Associated NFKB Activator (TANK) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for TRAF Family Member Associated NFKB Activator (TANK) CLIA Kit Customized Service Offer
n/a ELISA Kit for TRAF Family Member Associated NFKB Activator (TANK) ELISA Kit Customized Service Offer
  1. "I-TRAF is a novel TRAF-interacting protein that regulates TRAF-mediated signal transduction."Proc. Natl. Acad. Sci. U.S.A. 93:8241-8246(1996) [PubMed] [Europe PMC] [Abstract]
  2. "Tumor necrosis factor receptor associated factor 2 is a mediator of NF-kappa B activation by latent infection membrane protein 1, the Epstein-Barr virus transforming protein."Proc. Natl. Acad. Sci. U.S.A. 93:11085-11090(1996) [PubMed] [Europe PMC] [Abstract]
  3. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4." Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "NF-kB activation by a signaling complex containing TRAF2, TANK, and TBK1, a novel IKK-related kinase."EMBO J. 18:6694-6704(1999) [PubMed] [Europe PMC] [Abstract]
  6. "NF-kappaB activation through IKK-i-dependent I-TRAF/TANK phosphorylation."Genes Cells 5:191-202(2000) [PubMed] [Europe PMC] [Abstract]
  7. "Association of the adaptor TANK with the I kappa B kinase (IKK) regulator NEMO connects IKK complexes with IKK epsilon and TBK1 kinases."J. Biol. Chem. 277:37029-37036(2002) [PubMed] [Europe PMC] [Abstract]
  8. "SINTBAD, a novel component of innate antiviral immunity, shares a TBK1-binding domain with NAP1 and TANK."EMBO J. 26:3180-3190(2007) [PubMed] [Europe PMC] [Abstract]
  9. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
  10. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  11. "Large-scale proteomics analysis of the human kinome."Mol. Cell. Proteomics 8:1751-1764(2009) [PubMed] [Europe PMC] [Abstract]
  12. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  13. "Functional dissection of the TBK1 molecular network."PLoS ONE 6:E23971-E23971(2011) [PubMed] [Europe PMC] [Abstract]
  14. "N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]
  15. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  16. "Downstream regulator TANK binds to the CD40 recognition site on TRAF3."Structure 10:403-411(2002) [PubMed] [Europe PMC] [Abstract]