Phosphoinositide-3-Kinase Class-2-Gamma Polypeptide (PIK3C2g)

PIK3C2g belongs to the phosphoinositide 3-kinase (PI3K) family. PI3-kinases play roles in signaling pathways involved in cell proliferation, oncogenic transformation, cell survival, cell migration, and intracellular protein trafficking. This protein contains a lipid kinase catalytic domain as well as a C-terminal C2 domain, a characteristic of class II PI3-kinases. C2 domains act as calcium-dependent phospholipid binding motifs that mediate translocation of proteins to membranes, and may also mediate protein-protein interactions. The biological function of this gene has not yet been determined.The deduced 1,486-amino acid protein contains an N-terminal RAS-binding domain followed by a C2 domain, a PIK domain, a catalytic domain, a PX domain, and a C-terminal C2 domain.