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Phosphoinositide-3-Kinase Catalytic Gamma Polypeptide (PIK3Cg)

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PI3K; PI3CG; PI3Kgamma; PIK3; Phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit gamma; Serine/threonine protein kinase PIK3CG

Phosphoinositide-3-Kinase Catalytic Gamma Polypeptide (PIK3Cg)
CCC J831
HGNC 8978
MGI 1353576
PubMed 14627686
RGD 1306468
UniProt P48736
Wiki PIK3CG
PIK3Cg encodes a protein that belongs to the pi3/pi4-kinase family of proteins. The gene product is an enzyme that phosphorylates phosphoinositides on the 3-hydroxyl group of the inositol ring. It is an important modulator of extracellular signals, including those elicited by E-cadherin-mediated cell-cell adhesion, which plays an important role in maintenance of the structural and functional integrity of epithelia.
In addition to its role in promoting assembly of adherens junctions, the protein is thought to play a pivotal role in the regulation of cytotoxicity in NK cells. The gene is located in a commonly deleted segment of chromosome 7 previously identified in myeloid leukemias.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Phosphoinositide-3-Kinase Catalytic Gamma Polypeptide (PIK3Cg) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Phosphoinositide-3-Kinase Catalytic Gamma Polypeptide (PIK3Cg) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Phosphoinositide-3-Kinase Catalytic Gamma Polypeptide (PIK3Cg) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Phosphoinositide-3-Kinase Catalytic Gamma Polypeptide (PIK3Cg) CLIA Kit Customized Service Offer
n/a ELISA Kit for Phosphoinositide-3-Kinase Catalytic Gamma Polypeptide (PIK3Cg) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Phosphoinositide-3-Kinase Catalytic Gamma Polypeptide (PIK3Cg) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Phosphoinositide-3-Kinase Catalytic Gamma Polypeptide (PIK3Cg) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Phosphoinositide-3-Kinase Catalytic Gamma Polypeptide (PIK3Cg) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Phosphoinositide-3-Kinase Catalytic Gamma Polypeptide (PIK3Cg) CLIA Kit Customized Service Offer
n/a ELISA Kit for Phosphoinositide-3-Kinase Catalytic Gamma Polypeptide (PIK3Cg) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Phosphoinositide-3-Kinase Catalytic Gamma Polypeptide (PIK3Cg) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Phosphoinositide-3-Kinase Catalytic Gamma Polypeptide (PIK3Cg) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Phosphoinositide-3-Kinase Catalytic Gamma Polypeptide (PIK3Cg) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Phosphoinositide-3-Kinase Catalytic Gamma Polypeptide (PIK3Cg) CLIA Kit Customized Service Offer
n/a ELISA Kit for Phosphoinositide-3-Kinase Catalytic Gamma Polypeptide (PIK3Cg) ELISA Kit Customized Service Offer
  1. "Cloning and characterization of a G protein-activated human phosphoinositide-3 kinase."Science 269:690-693(1995) [PubMed] [Europe PMC] [Abstract]
  2. "The DNA sequence of human chromosome 7." Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
  3. "Human chromosome 7: DNA sequence and biology." Science 300:767-772(2003) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "The EphA8 receptor regulates integrin activity through p110gamma phosphatidylinositol-3 kinase in a tyrosine kinase activity-independent manner."Mol. Cell. Biol. 21:4579-4597(2001) [PubMed] [Europe PMC] [Abstract]
  6. "Phosphoinositide 3-kinase regulates beta2-adrenergic receptor endocytosis by AP-2 recruitment to the receptor/beta-arrestin complex."J. Cell Biol. 158:563-575(2002) [PubMed] [Europe PMC] [Abstract]
  7. "Identification and characterization of the autophosphorylation sites of phosphoinositide 3-kinase isoforms beta and gamma."J. Biol. Chem. 278:11536-11545(2003) [PubMed] [Europe PMC] [Abstract]
  8. "PI3Kgamma modulates the cardiac response to chronic pressure overload by distinct kinase-dependent and -independent effects."Cell 118:375-387(2004) [PubMed] [Europe PMC] [Abstract]
  9. "p84, a new Gbetagamma-activated regulatory subunit of the type IB phosphoinositide 3-kinase p110gamma."Curr. Biol. 15:566-570(2005) [PubMed] [Europe PMC] [Abstract]
  10. "Protein kinase activity of phosphoinositide 3-kinase regulates beta-adrenergic receptor endocytosis."Nat. Cell Biol. 7:785-796(2005) [PubMed] [Europe PMC] [Abstract]
  11. "PI3K delta and PI3K gamma: partners in crime in inflammation in rheumatoid arthritis and beyond?"Nat. Rev. Immunol. 7:191-201(2007) [PubMed] [Europe PMC] [Abstract]
  12. "Targeting phosphoinositide 3-kinase gamma to fight inflammation and more."Thromb. Haemost. 99:279-285(2008) [PubMed] [Europe PMC] [Abstract]
  13. "Cardiac regulation by phosphoinositide 3-kinases and PTEN."Cardiovasc. Res. 82:250-260(2009) [PubMed] [Europe PMC] [Abstract]
  14. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  15. "A phosphodiesterase 3B-based signaling complex integrates exchange protein activated by cAMP 1 and phosphatidylinositol 3-kinase signals in human arterial endothelial cells."J. Biol. Chem. 286:16285-16296(2011) [PubMed] [Europe PMC] [Abstract]
  16. "Structural insights into phosphoinositide 3-kinase catalysis and signalling."Nature 402:313-320(1999) [PubMed] [Europe PMC] [Abstract]
  17. "Blockade of PI3Kgamma suppresses joint inflammation and damage in mouse models of rheumatoid arthritis."Nat. Med. 11:936-943(2005) [PubMed] [Europe PMC] [Abstract]