Androgen Receptor N-Terminal Interacting Protein (ARNIP)
[Edit]RCHY1; CHIMP; PIRH2; ZNF363; RNF199; hARNIP; RING Finger And CHY Zinc Finger Domain-Containing Protein 1; Zinc Finger Protein 363; p53-induced RING-H2 protein
ARNIP has ubiquitin-protein ligase activity. This protein binds with p53 and promotes the ubiquitin-mediated proteosomal degradation of p53. This gene is oncogenic because loss of p53 function contributes directly to malignant tumor development. ARNIP contains a RING-H2 (C3H2C3) finger domain, which is capable of coordinating zinc ions, and several putative phosphorylation sites. ARNIP shares 90.4% amino acid identity with mouse Arnip and significant homology with Arnip from several other vertebrate and invertebrate species. All cysteine and histidine residues in the C3H2C3 RING motif are conserved between species. Northern blot analysis of mouse tissues detected a major transcript of about 1.7 kb expressed at highest levels in testis, at moderate levels in kidney, and at low levels in all other tissues examined.
Organism species: Homo sapiens (Human)
CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
Proteins | n/a | Recombinant Androgen Receptor N-Terminal Interacting Protein (ARNIP) | Recombinant Protein Customized Service Offer |
Antibodies | n/a | Monoclonal Antibody to Androgen Receptor N-Terminal Interacting Protein (ARNIP) | Monoclonal Antibody Customized Service Offer |
n/a | Polyclonal Antibody to Androgen Receptor N-Terminal Interacting Protein (ARNIP) | Polyclonal Antibody Customized Service Offer | |
Assay Kits | n/a | CLIA Kit for Androgen Receptor N-Terminal Interacting Protein (ARNIP) | CLIA Kit Customized Service Offer |
n/a | ELISA Kit for Androgen Receptor N-Terminal Interacting Protein (ARNIP) | ELISA Kit Customized Service Offer |
Organism species: Mus musculus (Mouse)
CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
Proteins | n/a | Recombinant Androgen Receptor N-Terminal Interacting Protein (ARNIP) | Recombinant Protein Customized Service Offer |
Antibodies | n/a | Monoclonal Antibody to Androgen Receptor N-Terminal Interacting Protein (ARNIP) | Monoclonal Antibody Customized Service Offer |
n/a | Polyclonal Antibody to Androgen Receptor N-Terminal Interacting Protein (ARNIP) | Polyclonal Antibody Customized Service Offer | |
Assay Kits | n/a | CLIA Kit for Androgen Receptor N-Terminal Interacting Protein (ARNIP) | CLIA Kit Customized Service Offer |
n/a | ELISA Kit for Androgen Receptor N-Terminal Interacting Protein (ARNIP) | ELISA Kit Customized Service Offer |
Organism species: Rattus norvegicus (Rat)
CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
Proteins | n/a | Recombinant Androgen Receptor N-Terminal Interacting Protein (ARNIP) | Recombinant Protein Customized Service Offer |
Antibodies | n/a | Monoclonal Antibody to Androgen Receptor N-Terminal Interacting Protein (ARNIP) | Monoclonal Antibody Customized Service Offer |
n/a | Polyclonal Antibody to Androgen Receptor N-Terminal Interacting Protein (ARNIP) | Polyclonal Antibody Customized Service Offer | |
Assay Kits | n/a | CLIA Kit for Androgen Receptor N-Terminal Interacting Protein (ARNIP) | CLIA Kit Customized Service Offer |
n/a | ELISA Kit for Androgen Receptor N-Terminal Interacting Protein (ARNIP) | ELISA Kit Customized Service Offer |
- "Identification and characterization of two novel isoforms of Pirh2 ubiquitin ligase that negatively regulate p53 independent of RING finger domains."J. Biol. Chem. 284:21955-21970(2009) [PubMed] [Europe PMC] [Abstract]
- "A novel hPirh2 splicing variant without ubiquitin protein ligase activity interacts with p53 and is down-regulated in hepatocellular carcinoma."FEBS Lett. 584:2772-2778(2010) [PubMed] [Europe PMC] [Abstract]
- "Identification of Pirh2D, an additional novel isoform of Pirh2 ubiquitin ligase."Mol. Cell. Pharmacol. 2:21-23(2010) [PubMed] [Europe PMC] [Abstract]
- "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
- "Generation and annotation of the DNA sequences of human chromosomes 2 and 4." Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
- "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
- "Control of human PIRH2 protein stability: involvement of TIP60 and the proteosome."J. Biol. Chem. 279:11696-11704(2004) [PubMed] [Europe PMC] [Abstract]
- "A new human gene hNTKL-BP1 interacts with hPirh2."Biochem. Biophys. Res. Commun. 330:293-297(2005) [PubMed] [Europe PMC] [Abstract]
- "Human PIRH2 enhances androgen receptor signaling through inhibition of histone deacetylase 1 and is overexpressed in prostate cancer."Mol. Cell. Biol. 26:6502-6510(2006) [PubMed] [Europe PMC] [Abstract]
- "PLAGL2 controls the stability of Pirh2, an E3 ubiquitin ligase for p53."Biochem. Biophys. Res. Commun. 364:344-350(2007) [PubMed] [Europe PMC] [Abstract]
- "Pirh2 promotes ubiquitin-dependent degradation of the cyclin-dependent kinase inhibitor p27Kip1."Cancer Res. 67:10789-10795(2007) [PubMed] [Europe PMC] [Abstract]
- "Phosphoproteome of resting human platelets."J. Proteome Res. 7:526-534(2008) [PubMed] [Europe PMC] [Abstract]
- "Ubiquitylation of epsilon-COP by PIRH2 and regulation of the secretion of PSA."Mol. Cell. Biochem. 307:73-82(2008) [PubMed] [Europe PMC] [Abstract]
- "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
- "Pirh2, a ubiquitin E3 ligase, inhibits p73 transcriptional activity by promoting its ubiquitination."Mol. Cancer Res. 9:1780-1790(2011) [PubMed] [Europe PMC] [Abstract]
- "Pirh2 E3 ubiquitin ligase monoubiquitinates DNA polymerase eta to suppress translesion DNA synthesis."Mol. Cell. Biol. 31:3997-4006(2011) [PubMed] [Europe PMC] [Abstract]
- "Molecular basis of Pirh2-mediated p53 ubiquitylation."Nat. Struct. Mol. Biol. 15:1334-1342(2008) [PubMed] [Europe PMC] [Abstract]