≡

SWI/SNF Related, Matrix Associated, Actin Dependent Regulator Of Chromatin, Subfamily A, Member 5 (SMARCA5)

[Edit]

ISWI; SNF2H; WCRF135; hISWI; hSNF2H; Sucrose nonfermenting protein 2 homolog

SWI/SNF Related, Matrix Associated, Actin Dependent Regulator Of Chromatin, Subfamily A, Member 5 (SMARCA5)
CCC J855
HGNC 11101
MGI 1935129
PubMed 23264744
RGD 1308832
UniProt O60264
Wiki SMARCA5
SMARCA5 is a member of the SWI/SNF family of proteins. Members of this family have helicase and ATPase activities and are thought to regulate transcription of certain genes by altering the chromatin structure around those genes. The protein encoded by this gene is a component of the chromatin remodeling and spacing factor RSF, a facilitator of the transcription of class II genes by RNA polymerase II. The encoded protein is similar in sequence to the Drosophila ISWI chromatin remodeling protein.The gene encodes a 1,052-amino acid polypeptide that is most closely related to Drosophila 'imitation switch' (ISWI) and human SNF2L1 . The protein has a leucine-zipper motif within the ATPase domain. Northern blot analysis showed that the gene was expressed as 4.1- and 5.1-kb mRNAs in all 16 human tissues tested.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant SWI/SNF Related, Matrix Associated, Actin Dependent Regulator Of Chromatin, Subfamily A, Member 5 (SMARCA5) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to SWI/SNF Related, Matrix Associated, Actin Dependent Regulator Of Chromatin, Subfamily A, Member 5 (SMARCA5) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to SWI/SNF Related, Matrix Associated, Actin Dependent Regulator Of Chromatin, Subfamily A, Member 5 (SMARCA5) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for SWI/SNF Related, Matrix Associated, Actin Dependent Regulator Of Chromatin, Subfamily A, Member 5 (SMARCA5) CLIA Kit Customized Service Offer
n/a ELISA Kit for SWI/SNF Related, Matrix Associated, Actin Dependent Regulator Of Chromatin, Subfamily A, Member 5 (SMARCA5) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant SWI/SNF Related, Matrix Associated, Actin Dependent Regulator Of Chromatin, Subfamily A, Member 5 (SMARCA5) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to SWI/SNF Related, Matrix Associated, Actin Dependent Regulator Of Chromatin, Subfamily A, Member 5 (SMARCA5) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to SWI/SNF Related, Matrix Associated, Actin Dependent Regulator Of Chromatin, Subfamily A, Member 5 (SMARCA5) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for SWI/SNF Related, Matrix Associated, Actin Dependent Regulator Of Chromatin, Subfamily A, Member 5 (SMARCA5) CLIA Kit Customized Service Offer
n/a ELISA Kit for SWI/SNF Related, Matrix Associated, Actin Dependent Regulator Of Chromatin, Subfamily A, Member 5 (SMARCA5) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant SWI/SNF Related, Matrix Associated, Actin Dependent Regulator Of Chromatin, Subfamily A, Member 5 (SMARCA5) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to SWI/SNF Related, Matrix Associated, Actin Dependent Regulator Of Chromatin, Subfamily A, Member 5 (SMARCA5) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to SWI/SNF Related, Matrix Associated, Actin Dependent Regulator Of Chromatin, Subfamily A, Member 5 (SMARCA5) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for SWI/SNF Related, Matrix Associated, Actin Dependent Regulator Of Chromatin, Subfamily A, Member 5 (SMARCA5) CLIA Kit Customized Service Offer
n/a ELISA Kit for SWI/SNF Related, Matrix Associated, Actin Dependent Regulator Of Chromatin, Subfamily A, Member 5 (SMARCA5) ELISA Kit Customized Service Offer
  1. "Cloning and mapping of SMARCA5 encoding hSNF2H, a novel human homologue of Drosophila ISWI."Cytogenet. Cell Genet. 81:191-193(1998) [PubMed] [Europe PMC] [Abstract]
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  3. "HuCHRAC, a human ISWI chromatin remodelling complex contains hACF1 and two novel histone-fold proteins."EMBO J. 19:3377-3387(2000) [PubMed] [Europe PMC] [Abstract]
  4. "Chromatin remodeling gene SMARCA5 is dysregulated in primitive hematopoietic cells of acute leukemia."Leukemia 14:1247-1252(2000) [PubMed] [Europe PMC] [Abstract]
  5. "A family of chromatin remodeling factors related to Williams syndrome transcription factor."Proc. Natl. Acad. Sci. U.S.A. 97:1038-1043(2000) [PubMed] [Europe PMC] [Abstract]
  6. "Functional differences between the human ATP-dependent nucleosome remodeling proteins BRG1 and SNF2H."J. Biol. Chem. 276:34270-34278(2001) [PubMed] [Europe PMC] [Abstract]
  7. "WSTF-ISWI chromatin remodeling complex targets heterochromatic replication foci."EMBO J. 21:2231-2241(2002) [PubMed] [Europe PMC] [Abstract]
  8. "An ACF1-ISWI chromatin-remodeling complex is required for DNA replication through heterochromatin."Nat. Genet. 32:627-632(2002) [PubMed] [Europe PMC] [Abstract]
  9. "A chromatin remodelling complex that loads cohesin onto human chromosomes."Nature 418:994-998(2002) [PubMed] [Europe PMC] [Abstract]
  10. "Functional analysis of the subunits of the chromatin assembly factor RSF."Mol. Cell. Biol. 23:6759-6768(2003) [PubMed] [Europe PMC] [Abstract]
  11. "Functional diversity of ISWI complexes."Biochem. Cell Biol. 82:482-489(2004) [PubMed] [Europe PMC] [Abstract]
  12. "The Williams syndrome transcription factor interacts with PCNA to target chromatin remodelling by ISWI to replication foci."Nat. Cell Biol. 6:1236-1244(2004) [PubMed] [Europe PMC] [Abstract]
  13. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
  14. "The WSTF-SNF2h chromatin remodeling complex interacts with several nuclear proteins in transcription."J. Biol. Chem. 281:16264-16271(2006) [PubMed] [Europe PMC] [Abstract]
  15. "Quantitative phosphoproteome profiling of Wnt3a-mediated signaling network: indicating the involvement of ribonucleoside-diphosphate reductase M2 subunit phosphorylation at residue serine 20 in canonical Wnt signal transduction."Mol. Cell. Proteomics 6:1952-1967(2007) [PubMed] [Europe PMC] [Abstract]
  16. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
  17. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  18. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
  19. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  20. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
  21. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  22. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  23. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  24. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]