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Rho/Cdc42 Guanine Nucleotide Exchange Factor 6 (ARHGEF6)

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COOL2; Cool-2; MRX46; PIXA; alpha-PIX; alphaPIX; PAK-Interacting Exchange Factor,Alpha; Rho Guanine Nucleotide Exchange Factor 6

Rho/Cdc42 Guanine Nucleotide Exchange Factor 6 (ARHGEF6)
CCC J856
HGNC 685
MGI 1920591
PubMed 19918261
RGD 1359674
UniProt Q15052
Wiki ARHGEF6
ARHGEF6 belongs to a family of cytoplasmic proteins that activate the Ras-like family of Rho proteins by exchanging bound GDP for GTP. It may form a complex with G proteins and stimulate Rho-dependent signals. This protein is activated by PI3-kinase. Mutations in this gene can cause X-chromosomal non-specific mental retardation.
Sequence analysis predicted that the 776-amino acid PIXA protein contains an N-terminal SH3 domain, a Dbl-homology (DH) domain, and a pleckstrin homology (PH) domain, suggestive of a Rho GEF. Northern blot analysis detected an approximately 5.0-kb transcript in heart, muscle, thymus, spleen, and placenta, with lower expression in brain, prostate, and testis, and little or no expression in lung, liver, and kidney.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Rho/Cdc42 Guanine Nucleotide Exchange Factor 6 (ARHGEF6) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Rho/Cdc42 Guanine Nucleotide Exchange Factor 6 (ARHGEF6) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Rho/Cdc42 Guanine Nucleotide Exchange Factor 6 (ARHGEF6) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Rho/Cdc42 Guanine Nucleotide Exchange Factor 6 (ARHGEF6) CLIA Kit Customized Service Offer
n/a ELISA Kit for Rho/Cdc42 Guanine Nucleotide Exchange Factor 6 (ARHGEF6) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Rho/Cdc42 Guanine Nucleotide Exchange Factor 6 (ARHGEF6) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Rho/Cdc42 Guanine Nucleotide Exchange Factor 6 (ARHGEF6) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Rho/Cdc42 Guanine Nucleotide Exchange Factor 6 (ARHGEF6) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Rho/Cdc42 Guanine Nucleotide Exchange Factor 6 (ARHGEF6) CLIA Kit Customized Service Offer
n/a ELISA Kit for Rho/Cdc42 Guanine Nucleotide Exchange Factor 6 (ARHGEF6) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Rho/Cdc42 Guanine Nucleotide Exchange Factor 6 (ARHGEF6) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Rho/Cdc42 Guanine Nucleotide Exchange Factor 6 (ARHGEF6) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Rho/Cdc42 Guanine Nucleotide Exchange Factor 6 (ARHGEF6) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Rho/Cdc42 Guanine Nucleotide Exchange Factor 6 (ARHGEF6) CLIA Kit Customized Service Offer
n/a ELISA Kit for Rho/Cdc42 Guanine Nucleotide Exchange Factor 6 (ARHGEF6) ELISA Kit Customized Service Offer
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  2. "The full-ORF clone resource of the German cDNA consortium."BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
  3. "The DNA sequence of the human X chromosome." Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Mutations in ARHGEF6, encoding a guanine nucleotide exchange factor for Rho GTPases, in patients with X-linked mental retardation."Nat. Genet. 26:247-250(2000) [PubMed] [Europe PMC] [Abstract]
  6. "Prediction of the coding sequences of unidentified human genes. I. The coding sequences of 40 new genes (KIAA0001-KIAA0040) deduced by analysis of randomly sampled cDNA clones from human immature myeloid cell line KG-1."DNA Res. 1:27-35(1994) [PubMed] [Europe PMC] [Abstract]
  7. "Characterization of ARHGEF6, a guanine nucleotide exchange factor for Rho GTPases and a candidate gene for X-linked mental retardation: mutation screening in Borjeson-Forssman-Lehmann syndrome and MRX27."Am. J. Med. Genet. 100:43-48(2001) [PubMed] [Europe PMC] [Abstract]
  8. "Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry."Anal. Chem. 76:2763-2772(2004) [PubMed] [Europe PMC] [Abstract]
  9. "The first CH domain of affixin activates Cdc42 and Rac1 through alphaPIX, a Cdc42/Rac1-specific guanine nucleotide exchanging factor."Genes Cells 9:193-204(2004) [PubMed] [Europe PMC] [Abstract]
  10. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  11. "Bin2 is a membrane sculpting N-BAR protein that influences leucocyte podosomes, motility and phagocytosis."PLoS ONE 7:E52401-E52401(2012) [PubMed] [Europe PMC] [Abstract]
  12. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  13. "Solution structure of the CH domain and the SH3 domain in RAC/CDC42 guanine nucleotide exchange factor (GEF) 6."Submitted (FEB-2004) to the PDB data bank