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Msh Homeobox Protein 2 (MSX2)

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CRS2; FPP; HOX8; MSH; PFM; PFM1; Parietal Foramina 1

Msh Homeobox Protein 2 (MSX2)
CCC J861
HGNC 7392
MGI 97169
PubMed 15841209
RGD 3116
UniProt P35548
Wiki MSX2
MSX2 is a transcriptional repressor whose normal activity may establish a balance between survival and apoptosis of neural crest-derived cells required for proper craniofacial morphogenesis. The encoded protein may also have a role in promoting cell growth under certain conditions and may be an important target for the RAS signaling pathways. Mutations in this gene are associated with parietal foramina 1 and craniosynostosis type 2. In contrast, high expression of the MSX2 gene was detected in several cell lines derived from human tumors. In addition, they found that the full-length human MSX2 cDNA induced transformation in chicken myoblast cultures, supporting the view that MSX2 promotes rather than suppresses cell growth under certain conditions.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Msh Homeobox Protein 2 (MSX2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Msh Homeobox Protein 2 (MSX2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Msh Homeobox Protein 2 (MSX2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Msh Homeobox Protein 2 (MSX2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Msh Homeobox Protein 2 (MSX2) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Msh Homeobox Protein 2 (MSX2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Msh Homeobox Protein 2 (MSX2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Msh Homeobox Protein 2 (MSX2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Msh Homeobox Protein 2 (MSX2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Msh Homeobox Protein 2 (MSX2) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Msh Homeobox Protein 2 (MSX2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Msh Homeobox Protein 2 (MSX2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Msh Homeobox Protein 2 (MSX2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Msh Homeobox Protein 2 (MSX2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Msh Homeobox Protein 2 (MSX2) ELISA Kit Customized Service Offer
  1. "Expression of a human homeobox-containing gene is regulated by 1,25(OH)2D3 in bone cells."Biochim. Biophys. Acta 1174:11-16(1993) [PubMed] [Europe PMC] [Abstract]
  2. "A mutation in the homeodomain of the human MSX2 gene in a family affected with autosomal dominant craniosynostosis."Cell 75:443-450(1993) [PubMed] [Europe PMC] [Abstract]
  3. "Molecular cloning and expression of homeobox-containing genes during hard tissue development."Kokubyo Gakkai Zasshi 61:590-604(1994) [PubMed] [Europe PMC] [Abstract]
  4. "Characterization of two length cDNA for human MSX-2 from dental pulp-derived cells."DNA Seq. 8:87-92(1997) [PubMed] [Europe PMC] [Abstract]
  5. "The DNA sequence and comparative analysis of human chromosome 5." Nature 431:268-274(2004) [PubMed] [Europe PMC] [Abstract]
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  7. "Over-expression of HOX-8, the human homologue of the mouse Hox-8 homeobox gene, in human tumors."Biochem. Biophys. Res. Commun. 194:187-193(1993) [PubMed] [Europe PMC] [Abstract]
  8. "Identification of homeobox genes expressed in human haemopoietic progenitor cells."Gene 144:213-219(1994) [PubMed] [Europe PMC] [Abstract]
  9. "Regulation of osteocalcin gene expression by a novel Ku antigen transcription factor complex."J. Biol. Chem. 277:37280-37291(2002) [PubMed] [Europe PMC] [Abstract]
  10. "Parietal foramina with cleidocranial dysplasia is caused by mutation in MSX2."Eur. J. Hum. Genet. 11:892-895(2003) [PubMed] [Europe PMC] [Abstract]
  11. "Identification of mutations in the MSX2 homeobox gene in families affected with foramina parietalia permagna."Hum. Mol. Genet. 9:1251-1255(2000) [PubMed] [Europe PMC] [Abstract]
  12. "Functional haploinsufficiency of the human homeobox gene MSX2 causes defects in skull ossification."Nat. Genet. 24:387-390(2000) [PubMed] [Europe PMC] [Abstract]
  13. "Second family with the Boston-type craniosynostosis syndrome: novel mutation and expansion of the clinical spectrum."Am. J. Med. Genet. A 161A:2352-2357(2013) [PubMed] [Europe PMC] [Abstract]
  14. "Boston type craniosynostosis: report of a second mutation in MSX2."Am. J. Med. Genet. A 161:2626-2633(2013) [PubMed] [Europe PMC] [Abstract]