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MKL/Myocardin Like Protein 2 (MKL2)

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MRTF-B; NPD001; Myocardin-related transcription factor B; Megakaryoblastic leukemia 2

MKL/Myocardin Like Protein 2 (MKL2)
CCC J870
HGNC 29819
MGI 3050795
PubMed 20607705
UniProt Q9ULH7
Wiki MKL2
MKL2 was a strong transactivator of promoters containing serum response elements (SRE). Activation by MKL2 had a threshold effect in that 0.5 microgram caused little activation, whereas 2.0 microgram caused 40-fold activation. Gel mobility shift assays indicated that MKL2 did not bind DNA by itself, but formed a complex with SRF. Mutation analysis indicated that the N-terminal 71 amino acids of MKL2 repressed the interaction between MKL2 and SRF. The leucine zipper-like domain of MKL2 promoted interaction with itself and with MKL1, as well as contributed to transactivation. The transcriptional activation domain of MKL2 was mapped to the C terminus, and the region from amino acid 701 to the C terminus showed higher transcriptional activity than the full-length protein.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant MKL/Myocardin Like Protein 2 (MKL2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to MKL/Myocardin Like Protein 2 (MKL2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to MKL/Myocardin Like Protein 2 (MKL2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for MKL/Myocardin Like Protein 2 (MKL2) CLIA Kit Customized Service Offer
n/a ELISA Kit for MKL/Myocardin Like Protein 2 (MKL2) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant MKL/Myocardin Like Protein 2 (MKL2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to MKL/Myocardin Like Protein 2 (MKL2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to MKL/Myocardin Like Protein 2 (MKL2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for MKL/Myocardin Like Protein 2 (MKL2) CLIA Kit Customized Service Offer
n/a ELISA Kit for MKL/Myocardin Like Protein 2 (MKL2) ELISA Kit Customized Service Offer
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