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MKL/Myocardin Like Protein 1 (MKL1)

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MAL; BSAC; MRTF-A; Megakaryoblastic Leukemia(Translocation)1; Megakaryocytic Acute Leukemia; Myocardin-Related Transcription Factor A; Basic,SAP And Coiled-Coil Domain

MKL/Myocardin Like Protein 1 (MKL1)
CCC J871
HGNC 14334
MGI 2384495
PubMed 19136660
RGD 1304873
UniProt Q969V6
Wiki MKL1
MKL1 interacts with the transcription factor myocardin, a key regulator of smooth muscle cell differentiation. The encoded protein is predominantly nuclear and may help transduce signals from the cytoskeleton to the nucleus. This gene is involved in a specific translocation event that creates a fusion of this gene and the RNA-binding motif protein-15 gene.
The protein contains an N-terminal domain, followed by a basic region, a glutamine-rich region, a SAP domain, and a coiled-coil region. Epitope-tagged MKL1 was expressed as a nuclear protein of about 160 kD.Deletion of the first 250 amino acids of MKL1, including the N-terminal domain and the basic region, abolished its transcriptional activity and caused a relocalization of the protein from the nucleus to the cytoplasm.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant MKL/Myocardin Like Protein 1 (MKL1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to MKL/Myocardin Like Protein 1 (MKL1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to MKL/Myocardin Like Protein 1 (MKL1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for MKL/Myocardin Like Protein 1 (MKL1) CLIA Kit Customized Service Offer
n/a ELISA Kit for MKL/Myocardin Like Protein 1 (MKL1) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant MKL/Myocardin Like Protein 1 (MKL1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to MKL/Myocardin Like Protein 1 (MKL1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to MKL/Myocardin Like Protein 1 (MKL1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for MKL/Myocardin Like Protein 1 (MKL1) CLIA Kit Customized Service Offer
n/a ELISA Kit for MKL/Myocardin Like Protein 1 (MKL1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant MKL/Myocardin Like Protein 1 (MKL1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to MKL/Myocardin Like Protein 1 (MKL1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to MKL/Myocardin Like Protein 1 (MKL1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for MKL/Myocardin Like Protein 1 (MKL1) CLIA Kit Customized Service Offer
n/a ELISA Kit for MKL/Myocardin Like Protein 1 (MKL1) ELISA Kit Customized Service Offer
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