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Polymerase DNA Directed Delta 2 (POLd2)

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DNA polymerase delta subunit p50

Polymerase DNA Directed Delta 2 (POLd2)
CCC J874
HGNC 9176
MGI 1097163
PubMed 8530069
RGD 1304954
UniProt P49005
Wiki POLD2
The DNA polymerase delta complex is involved in DNA replication and repair, and it consists of the proliferating cell nuclear antigen (PCNA), the multisubunit replication factor C, and the 4 subunit polymerase complex: POLD1, POLD2, POLD3, and POLD4.
POLD2,The predicted bovine and human polypeptides of 50.9 and 51.3 kD, respectively, are 94% identical, similar to the identity of the bovine and human catalytic POLD1 subunits. The high degree of conservation of the polypeptides suggested an essential function for the small subunit in the heterodimeric core enzyme. Searches of protein databases failed to detect significant homology with any protein sequenced to that point.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Polymerase DNA Directed Delta 2 (POLd2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Polymerase DNA Directed Delta 2 (POLd2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Polymerase DNA Directed Delta 2 (POLd2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Polymerase DNA Directed Delta 2 (POLd2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Polymerase DNA Directed Delta 2 (POLd2) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Polymerase DNA Directed Delta 2 (POLd2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Polymerase DNA Directed Delta 2 (POLd2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Polymerase DNA Directed Delta 2 (POLd2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Polymerase DNA Directed Delta 2 (POLd2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Polymerase DNA Directed Delta 2 (POLd2) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Polymerase DNA Directed Delta 2 (POLd2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Polymerase DNA Directed Delta 2 (POLd2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Polymerase DNA Directed Delta 2 (POLd2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Polymerase DNA Directed Delta 2 (POLd2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Polymerase DNA Directed Delta 2 (POLd2) ELISA Kit Customized Service Offer
  1. "Cloning of the cDNAs for the small subunits of bovine and human DNA polymerase delta and chromosomal location of the human gene (POLD2)."Genomics 29:179-186(1995) [PubMed] [Europe PMC] [Abstract]
  2. "Characterization of the 5'-flanking region of the gene encoding the 50 kDa subunit of human DNA polymerase delta."Biochim. Biophys. Acta 1493:231-236(2000) [PubMed] [Europe PMC] [Abstract]
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  4. "Human chromosome 7: DNA sequence and biology." Science 300:767-772(2003) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "A tumor necrosis factor alpha- and interleukin 6-inducible protein that interacts with the small subunit of DNA polymerase delta and proliferating cell nuclear antigen."Proc. Natl. Acad. Sci. U.S.A. 98:11979-11984(2001) [PubMed] [Europe PMC] [Abstract]
  7. "Identification of a novel protein, PDIP38, that interacts with the p50 subunit of DNA polymerase delta and proliferating cell nuclear antigen."J. Biol. Chem. 278:10041-10047(2003) [PubMed] [Europe PMC] [Abstract]
  8. "Human Werner helicase interacting protein 1 (WRNIP1) functions as a novel modulator for DNA polymerase delta."Genes Cells 10:13-22(2005) [PubMed] [Europe PMC] [Abstract]
  9. "Functional roles of p12, the fourth subunit of human DNA polymerase delta."J. Biol. Chem. 281:14748-14755(2006) [PubMed] [Europe PMC] [Abstract]
  10. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  11. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  12. "Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features."Mol. Cell. Proteomics 11:M111.015131-M111.015131(2012) [PubMed] [Europe PMC] [Abstract]
  13. "N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]