V-Src Sarcoma Viral Oncogene Homolog (SRC)

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ASV; SRC1; c-SRC; p60-Src; Proto-oncogene tyrosine-protein kinase Src

V-Src Sarcoma Viral Oncogene Homolog (SRC)
Src is a family of proto-oncogenic tyrosine kinases originally discovered by J. Michael Bishop and Harold E. Varmus, for which they won the 1989 Nobel Prize in Physiology or Medicine. The discovery of Src family proteins has been instrumental to the modern understanding of cancer as a disease where normally healthy cellular signalling has gone awry.
This proto-oncogene may play a role in the regulation of embryonic development and cell growth. The protein encoded by this gene is a tyrosine-protein kinase whose activity can be inhibited by phosphorylation by c-SRC kinase. Mutations in this gene could be involved in the malignant progression of colon cancer. Two transcript variants encoding the same protein have been found for this gene.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant V-Src Sarcoma Viral Oncogene Homolog (SRC) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to V-Src Sarcoma Viral Oncogene Homolog (SRC) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to V-Src Sarcoma Viral Oncogene Homolog (SRC) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for V-Src Sarcoma Viral Oncogene Homolog (SRC) CLIA Kit Customized Service Offer
n/a ELISA Kit for V-Src Sarcoma Viral Oncogene Homolog (SRC) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant V-Src Sarcoma Viral Oncogene Homolog (SRC) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to V-Src Sarcoma Viral Oncogene Homolog (SRC) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to V-Src Sarcoma Viral Oncogene Homolog (SRC) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for V-Src Sarcoma Viral Oncogene Homolog (SRC) CLIA Kit Customized Service Offer
n/a ELISA Kit for V-Src Sarcoma Viral Oncogene Homolog (SRC) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant V-Src Sarcoma Viral Oncogene Homolog (SRC) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to V-Src Sarcoma Viral Oncogene Homolog (SRC) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to V-Src Sarcoma Viral Oncogene Homolog (SRC) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for V-Src Sarcoma Viral Oncogene Homolog (SRC) CLIA Kit Customized Service Offer
n/a ELISA Kit for V-Src Sarcoma Viral Oncogene Homolog (SRC) ELISA Kit Customized Service Offer
  1. "The DNA sequence and comparative analysis of human chromosome 20." Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract]
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  3. "DNA sequence encoding the amino-terminal region of the human c-src protein: implications of sequence divergence among src-type kinase oncogenes."Mol. Cell. Biol. 7:1978-1983(1987) [PubMed] [Europe PMC] [Abstract]
  4. "Human cellular src gene: nucleotide sequence and derived amino acid sequence of the region coding for the carboxy-terminal two-thirds of pp60c-src."Mol. Cell. Biol. 5:1122-1129(1985) [PubMed] [Europe PMC] [Abstract]
  5. "Neuron-specific splicing of C-SRC RNA in human brain."J. Neurosci. Res. 24:89-96(1989) [PubMed] [Europe PMC] [Abstract]
  6. "Isolation of duplicated human c-src genes located on chromosomes 1 and 20."Mol. Cell. Biol. 5:831-838(1985) [PubMed] [Europe PMC] [Abstract]
  7. "Characterization of sites for tyrosine phosphorylation in the transforming protein of Rous sarcoma virus (pp60v-src) and its normal cellular homologue (pp60c-src)."Proc. Natl. Acad. Sci. U.S.A. 78:6013-6017(1981) [PubMed] [Europe PMC] [Abstract]
  8. "Analysis of pp60c-src protein kinase activity in human tumor cell lines and tissues."J. Biol. Chem. 261:13754-13759(1986) [PubMed] [Europe PMC] [Abstract]
  9. "pp60c-src activation in human colon carcinoma."J. Clin. Invest. 83:2025-2033(1989) [PubMed] [Europe PMC] [Abstract]
  10. "Identification of a novel neuronal C-SRC exon expressed in human brain."Mol. Cell. Biol. 10:2035-2040(1990) [PubMed] [Europe PMC] [Abstract]
  11. "Association of the amino-terminal half of c-Src with focal adhesions alters their properties and is regulated by phosphorylation of tyrosine 527."EMBO J. 13:4745-4756(1994) [PubMed] [Europe PMC] [Abstract]
  12. "Cdc2-mediated modulation of pp60c-src activity."J. Biol. Chem. 269:26885-26889(1994) [PubMed] [Europe PMC] [Abstract]
  13. "Highly specific antibody to Rous sarcoma virus src gene product recognizes nuclear and nucleolar antigens in human cells."J. Virol. 69:1699-1713(1995) [PubMed] [Europe PMC] [Abstract]
  14. "Physical and functional association of Fc mu receptor on human natural killer cells with the zeta- and Fc epsilon RI gamma-chains and with src family protein tyrosine kinases."J. Immunol. 157:1485-1491(1996) [PubMed] [Europe PMC] [Abstract]
  15. "Hepatocyte growth factor is a coupling factor for osteoclasts and osteoblasts in vitro."Proc. Natl. Acad. Sci. U.S.A. 93:7644-7648(1996) [PubMed] [Europe PMC] [Abstract]
  16. "Butein, a specific protein tyrosine kinase inhibitor."Biochem. Biophys. Res. Commun. 245:435-438(1998) [PubMed] [Europe PMC] [Abstract]
  17. "RACK1, a receptor for activated C kinase and a homolog of the beta subunit of G proteins, inhibits activity of src tyrosine kinases and growth of NIH 3T3 cells."Mol. Cell. Biol. 18:3245-3256(1998) [PubMed] [Europe PMC] [Abstract]
  18. "Beta-arrestin-dependent formation of beta2 adrenergic receptor-Src protein kinase complexes."Science 283:655-661(1999) [PubMed] [Europe PMC] [Abstract]
  19. "beta-arrestin1 interacts with the catalytic domain of the tyrosine kinase c-SRC. Role of beta-arrestin1-dependent targeting of c-SRC in receptor endocytosis."J. Biol. Chem. 275:11312-11319(2000) [PubMed] [Europe PMC] [Abstract]
  20. "Identification and characterization of a new family of guanine nucleotide exchange factors for the ras-related GTPase Ral."J. Biol. Chem. 275:13406-13410(2000) [PubMed] [Europe PMC] [Abstract]
  21. "Differential actions of p60c-Src and Lck kinases on the Ras regulators p120-GAP and GDP/GTP exchange factor CDC25Mm."Eur. J. Biochem. 268:3275-3283(2001) [PubMed] [Europe PMC] [Abstract]
  22. "The c-Src tyrosine kinase regulates signaling of the human DF3/MUC1 carcinoma-associated antigen with GSK3 beta and beta-catenin."J. Biol. Chem. 276:6061-6064(2001) [PubMed] [Europe PMC] [Abstract]
  23. "The interaction of Src and RACK1 is enhanced by activation of protein kinase C and tyrosine phosphorylation of RACK1."J. Biol. Chem. 276:20346-20356(2001) [PubMed] [Europe PMC] [Abstract]
  24. "The ORF3 protein of hepatitis E virus binds to Src homology 3 domains and activates MAPK."J. Biol. Chem. 276:42389-42400(2001) [PubMed] [Europe PMC] [Abstract]
  25. "Src-induced phosphorylation of caveolin-2 on tyrosine 19. Phospho-caveolin-2 (Tyr(P)19) is localized near focal adhesions, remains associated with lipid rafts/caveolae, but no longer forms a high molecular mass hetero-oligomer with caveolin-1."J. Biol. Chem. 277:34556-34567(2002) [PubMed] [Europe PMC] [Abstract]
  26. "Estrogen receptor-interacting protein that modulates its nongenomic activity-crosstalk with Src/Erk phosphorylation cascade."Proc. Natl. Acad. Sci. U.S.A. 99:14783-14788(2002) [PubMed] [Europe PMC] [Abstract]
  27. "Regulation of cytochrome c oxidase activity by c-Src in osteoclasts."J. Cell Biol. 160:709-718(2003) [PubMed] [Europe PMC] [Abstract]
  28. "EphB1 recruits c-Src and p52Shc to activate MAPK/ERK and promote chemotaxis."J. Cell Biol. 162:661-671(2003) [PubMed] [Europe PMC] [Abstract]
  29. "Development and characterization of potent and specific peptide inhibitors of p60c-src protein tyrosine kinase using pseudosubstrate-based inhibitor design approach."J. Pept. Res. 62:260-268(2003) [PubMed] [Europe PMC] [Abstract]
  30. "Pyk2- and Src-dependent tyrosine phosphorylation of PDK1 regulates focal adhesions."Mol. Cell. Biol. 23:8019-8029(2003) [PubMed] [Europe PMC] [Abstract]
  31. "Tyrosine phosphorylation of caveolin-2 at residue 27: differences in the spatial and temporal behavior of phospho-Cav-2 (pY19 and pY27)."Biochemistry 43:13694-13706(2004) [PubMed] [Europe PMC] [Abstract]
  32. "Cbl-c suppresses v-Src-induced transformation through ubiquitin-dependent protein degradation."Oncogene 23:1645-1655(2004) [PubMed] [Europe PMC] [Abstract]
  33. "The C2 domain of PKCdelta is a phosphotyrosine binding domain."Cell 121:271-280(2005) [PubMed] [Europe PMC] [Abstract]
  34. "Tyrosine 740 phosphorylation of discoidin domain receptor 2 by Src stimulates intramolecular autophosphorylation and Shc signaling complex formation."J. Biol. Chem. 280:39058-39066(2005) [PubMed] [Europe PMC] [Abstract]
  35. "The adaptor protein Tom1L1 is a negative regulator of Src mitogenic signaling induced by growth factors."Mol. Cell. Biol. 26:1932-1947(2006) [PubMed] [Europe PMC] [Abstract]
  36. "Gonadotropin-releasing hormone functionally antagonizes testosterone activation of the human androgen receptor in prostate cells through focal adhesion complexes involving Hic-5."Neuroendocrinology 84:285-300(2006) [PubMed] [Europe PMC] [Abstract]
  37. "Amotl2 is essential for cell movements in zebrafish embryo and regulates c-Src translocation."Development 134:979-988(2007) [PubMed] [Europe PMC] [Abstract]
  38. "p140Cap protein suppresses tumour cell properties, regulating Csk and Src kinase activity."EMBO J. 26:2843-2855(2007) [PubMed] [Europe PMC] [Abstract]
  39. "EGF mediates calcium-activated chloride channel activation in the human bronchial epithelial cell line 16HBE14o-: involvement of tyrosine kinase p60c-src."Am. J. Physiol. 295:L489-L496(2008) [PubMed] [Europe PMC] [Abstract]
  40. "Regulation of 3-phosphoinositide-dependent protein kinase-1 (PDK1) by Src involves tyrosine phosphorylation of PDK1 and Src homology 2 domain binding."J. Biol. Chem. 283:1480-1491(2008) [PubMed] [Europe PMC] [Abstract]
  41. "Phosphoproteome of resting human platelets."J. Proteome Res. 7:526-534(2008) [PubMed] [Europe PMC] [Abstract]
  42. "Regulation of estrogen rapid signaling through arginine methylation by PRMT1."Mol. Cell 31:212-221(2008) [PubMed] [Europe PMC] [Abstract]
  43. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
  44. "Identification of SH3 domain interaction partners of human FasL (CD178) by phage display screening."BMC Immunol. 10:53-53(2009) [PubMed] [Europe PMC] [Abstract]
  45. "The tyrosine kinase c-Src enhances RIG-I (retinoic acid-inducible gene I)-elicited antiviral signaling."J. Biol. Chem. 284:19122-19131(2009) [PubMed] [Europe PMC] [Abstract]
  46. "New role for the protein tyrosine phosphatase DEP-1 in Akt activation and endothelial cell survival."Mol. Cell. Biol. 29:241-253(2009) [PubMed] [Europe PMC] [Abstract]
  47. "Large-scale proteomics analysis of the human kinome."Mol. Cell. Proteomics 8:1751-1764(2009) [PubMed] [Europe PMC] [Abstract]
  48. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  49. "Heme controls the regulation of protein tyrosine kinases Jak2 and Src."Biochem. Biophys. Res. Commun. 403:30-35(2010) [PubMed] [Europe PMC] [Abstract]
  50. "Src kinase phosphorylates RUNX3 at tyrosine residues and localizes the protein in the cytoplasm."J. Biol. Chem. 285:10122-10129(2010) [PubMed] [Europe PMC] [Abstract]
  51. "The N terminus of Cbl-c regulates ubiquitin ligase activity by modulating affinity for the ubiquitin-conjugating enzyme."J. Biol. Chem. 285:23687-23698(2010) [PubMed] [Europe PMC] [Abstract]
  52. "Regulation of PTEN/Akt and MAP kinase signaling pathways by the ubiquitin ligase activators Ndfip1 and Ndfip2."Proc. Natl. Acad. Sci. U.S.A. 107:11429-11434(2010) [PubMed] [Europe PMC] [Abstract]
  53. "The Cdc42-associated kinase ACK1 is not auto-inhibited but requires Src for activation."Biochem. J. 435:355-364(2011) [PubMed] [Europe PMC] [Abstract]
  54. "Cdk5 targets active Src for ubiquitin-dependent degradation by phosphorylating Src(S75)."Cell. Mol. Life Sci. 68:3425-3436(2011) [PubMed] [Europe PMC] [Abstract]
  55. "Regulation, substrates and functions of src."Biochim. Biophys. Acta 1287:121-149(1996) [PubMed] [Europe PMC] [Abstract]
  56. "Cellular functions regulated by Src family kinases."Annu. Rev. Cell Dev. Biol. 13:513-609(1997) [PubMed] [Europe PMC] [Abstract]
  57. "Novel regulation and function of Src tyrosine kinase."Cell. Mol. Life Sci. 59:456-462(2002) [PubMed] [Europe PMC] [Abstract]
  58. "A direct interaction between the large GTPase dynamin-2 and FAK regulates focal adhesion dynamics in response to active Src."Mol. Biol. Cell 22:1529-1538(2011) [PubMed] [Europe PMC] [Abstract]
  59. "Identification and functional characterization of p130Cas as a substrate of protein tyrosine phosphatase nonreceptor 14."Oncogene 32:2087-2095(2013) [PubMed] [Europe PMC] [Abstract]
  60. "Molecular chaperone TRAP1 regulates a metabolic switch between mitochondrial respiration and aerobic glycolysis." Proc. Natl. Acad. Sci. U.S.A. 110:E1604-E1612(2013) [PubMed] [Europe PMC] [Abstract]
  61. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  62. "Three-dimensional structure of the tyrosine kinase c-Src."Nature 385:595-602(1997) [PubMed] [Europe PMC] [Abstract]
  63. "Peptide ligands of pp60(c-src) SH2 domains: a thermodynamic and structural study."Biochemistry 36:6283-6293(1997) [PubMed] [Europe PMC] [Abstract]
  64. "Solution structure of the human pp60c-src SH2 domain complexed with a phosphorylated tyrosine pentapeptide."Biochemistry 34:2107-2121(1995) [PubMed] [Europe PMC] [Abstract]
  65. "Structural flexibility regulates phosphopeptide-binding activity of the tyrosine kinase binding domain of Cbl-c."J. Biochem. 152:487-495(2012) [PubMed] [Europe PMC] [Abstract]
  66. "Patterns of somatic mutation in human cancer genomes." Nature 446:153-158(2007) [PubMed] [Europe PMC] [Abstract]