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WD Repeat Domain Phosphoinositide Interacting Protein 2 (WIPI2)

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Atg21; CGI-50; WIPI-2; WIPI49-like protein 2

WD Repeat Domain Phosphoinositide Interacting Protein 2 (WIPI2)
CCC J882
HGNC 32225
MGI 1923831
PubMed 20505359
RGD 1359154
UniProt Q9Y4P8
Wiki WIPI2
WD40 repeat proteins are key components of many essential biologic functions. They regulate the assembly of multiprotein complexes by presenting a beta-propeller platform for simultaneous and reversible protein-protein interactions. Members of the WIPI subfamily of WD40 repeat proteins, such as WIPI2, have a 7-bladed propeller structure and contain a conserved motif for interaction with phospholipids.
WIPI2 is the mammalian homolog of Atg18, not Atg21, along with the closely related protein, WIPI1. WIPI2 mRNA is readily detectable in several commonly used laboratory cell lines (HEK293A, HeLa, A431) and several cancer cell lines, while WIPI1 expression is limited to cancer cells.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant WD Repeat Domain Phosphoinositide Interacting Protein 2 (WIPI2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to WD Repeat Domain Phosphoinositide Interacting Protein 2 (WIPI2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to WD Repeat Domain Phosphoinositide Interacting Protein 2 (WIPI2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for WD Repeat Domain Phosphoinositide Interacting Protein 2 (WIPI2) CLIA Kit Customized Service Offer
n/a ELISA Kit for WD Repeat Domain Phosphoinositide Interacting Protein 2 (WIPI2) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant WD Repeat Domain Phosphoinositide Interacting Protein 2 (WIPI2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to WD Repeat Domain Phosphoinositide Interacting Protein 2 (WIPI2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to WD Repeat Domain Phosphoinositide Interacting Protein 2 (WIPI2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for WD Repeat Domain Phosphoinositide Interacting Protein 2 (WIPI2) CLIA Kit Customized Service Offer
n/a ELISA Kit for WD Repeat Domain Phosphoinositide Interacting Protein 2 (WIPI2) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant WD Repeat Domain Phosphoinositide Interacting Protein 2 (WIPI2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to WD Repeat Domain Phosphoinositide Interacting Protein 2 (WIPI2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to WD Repeat Domain Phosphoinositide Interacting Protein 2 (WIPI2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for WD Repeat Domain Phosphoinositide Interacting Protein 2 (WIPI2) CLIA Kit Customized Service Offer
n/a ELISA Kit for WD Repeat Domain Phosphoinositide Interacting Protein 2 (WIPI2) ELISA Kit Customized Service Offer
  1. "WIPI-1alpha (WIPI49), a member of the novel 7-bladed WIPI protein family, is aberrantly expressed in human cancer and is linked to starvation-induced autophagy."Oncogene 23:9314-9325(2004) [PubMed] [Europe PMC] [Abstract]
  2. "Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics."Genome Res. 10:703-713(2000) [PubMed] [Europe PMC] [Abstract]
  3. "Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs." Genome Res. 11:422-435(2001) [PubMed] [Europe PMC] [Abstract]
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  5. "The DNA sequence of human chromosome 7." Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  7. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  8. "Mammalian Atg18 (WIPI2) localizes to omegasome-anchored phagophores and positively regulates LC3 lipidation."Autophagy 6:506-522(2010) [PubMed] [Europe PMC] [Abstract]
  9. "A Tecpr1-dependent selective autophagy pathway targets bacterial pathogens."Cell Host Microbe 9:376-389(2011) [PubMed] [Europe PMC] [Abstract]
  10. "Freeze-fracture replica immunolabelling reveals human WIPI-1 and WIPI-2 as membrane proteins of autophagosomes."J. Cell. Mol. Med. 15:2007-2010(2011) [PubMed] [Europe PMC] [Abstract]
  11. "Dynamic and transient interactions of Atg9 with autophagosomes, but not membrane integration, are required for autophagy."Mol. Biol. Cell 23:1860-1873(2012) [PubMed] [Europe PMC] [Abstract]
  12. "Inhibition of LRRK2 kinase activity stimulates macroautophagy."Biochim. Biophys. Acta 1833:2900-2910(2013) [PubMed] [Europe PMC] [Abstract]
  13. "ZKSCAN3 is a master transcriptional repressor of autophagy."Mol. Cell 50:16-28(2013) [PubMed] [Europe PMC] [Abstract]
  14. "WIPI2 links LC3 conjugation with PI3P, autophagosome formation, and pathogen clearance by recruiting Atg12-5-16L1."Mol. Cell 55:238-252(2014) [PubMed] [Europe PMC] [Abstract]