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PIN2 Interacting Protein 1 (PINX1)

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LPTL; LPTS; Liver-Related Putative Tumor Suppressor; PIN2/TERF1 Interacting,Telomerase Inhibitor 1; Protein 67-11-3

PIN2 Interacting Protein 1 (PINX1)
CCC J904
HGNC 30046
MGI 1919650
PubMed 24412852
RGD 1566025
UniProt Q96BK5
Wiki PINX1
PINX1, was found to inhibit telomerase activity and affect tumorigenicity. The predicted 328-amino acid PINX1 protein has a gly-rich region in its N terminus and a telomerase inhibitory domain (TID) in its C terminus.
PINX1 encodes a 45-kD protein in cells.Overexpression of PINX1 or its TID inhibited telomerase activity, shortened telomeres, and induced crisis, whereas depletion of endogenous PINX1 increased telomerase activity and elongated telomeres. Depletion of PINX1 also increased tumorigenicity in nude mice, consistent with its localization at 8p23, a region with frequent loss of heterozygosity in a number of human cancers. The authors concluded that PINX1 is a potent telomerase inhibitor and a putative tumor suppressor.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant PIN2 Interacting Protein 1 (PINX1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to PIN2 Interacting Protein 1 (PINX1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to PIN2 Interacting Protein 1 (PINX1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for PIN2 Interacting Protein 1 (PINX1) CLIA Kit Customized Service Offer
n/a ELISA Kit for PIN2 Interacting Protein 1 (PINX1) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant PIN2 Interacting Protein 1 (PINX1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to PIN2 Interacting Protein 1 (PINX1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to PIN2 Interacting Protein 1 (PINX1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for PIN2 Interacting Protein 1 (PINX1) CLIA Kit Customized Service Offer
n/a ELISA Kit for PIN2 Interacting Protein 1 (PINX1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant PIN2 Interacting Protein 1 (PINX1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to PIN2 Interacting Protein 1 (PINX1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to PIN2 Interacting Protein 1 (PINX1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for PIN2 Interacting Protein 1 (PINX1) CLIA Kit Customized Service Offer
n/a ELISA Kit for PIN2 Interacting Protein 1 (PINX1) ELISA Kit Customized Service Offer
  1. "Identification of the gene for a novel liver-related putative tumor suppressor at a high-frequency loss of heterozygosity region of chromosome 8p23 in human hepatocellular carcinoma."Hepatology 32:721-727(2000) [PubMed] [Europe PMC] [Abstract]
  2. "The Pin2/TRF1-interacting protein PinX1 is a potent telomerase inhibitor."Cell 107:347-359(2001) [PubMed] [Europe PMC] [Abstract]
  3. Thesis (2001), University of Goettingen, Germany
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "Human MCRS2, a cell-cycle-dependent protein, associates with LPTS/PinX1 and reduces the telomere length."Biochem. Biophys. Res. Commun. 316:1116-1123(2004) [PubMed] [Europe PMC] [Abstract]
  7. "Characterization of interactions between PinX1 and human telomerase subunits hTERT and hTR."J. Biol. Chem. 279:51745-51748(2004) [PubMed] [Europe PMC] [Abstract]
  8. "Characterization of a novel effect of hPinX1 on hTERT nucleolar localization."Biochem. Biophys. Res. Commun. 353:946-952(2007) [PubMed] [Europe PMC] [Abstract]
  9. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  10. "A shared docking motif in TRF1 and TRF2 used for differential recruitment of telomeric proteins."Science 319:1092-1096(2008) [PubMed] [Europe PMC] [Abstract]
  11. "PinX1 is recruited to the mitotic chromosome periphery by nucleolin and facilitates chromosome congression."Biochem. Biophys. Res. Commun. 384:76-81(2009) [PubMed] [Europe PMC] [Abstract]
  12. "Silencing PinX1 compromises telomere length maintenance as well as tumorigenicity in telomerase-positive human cancer cells."Cancer Res. 69:75-83(2009) [PubMed] [Europe PMC] [Abstract]
  13. "PinX1 is a novel microtubule-binding protein essential for accurate chromosome segregation."J. Biol. Chem. 284:23072-23082(2009) [PubMed] [Europe PMC] [Abstract]
  14. "Human PinX1 mediates TRF1 accumulation in nucleolus and enhances TRF1 binding to telomeres."J. Mol. Biol. 388:928-940(2009) [PubMed] [Europe PMC] [Abstract]
  15. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  16. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  17. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]