MAS Related GPR Member X1 (MRGPRX1)
[Edit]GPCR; MRGX1; SNSR4; Sensory neuron-specific G-protein coupled receptor 3/4
Dong et al. (2001) identified, in the mouse and human genomes, a family of G protein-coupled receptors (GPCRs) related to the MAS1 oncogene, including MRGX1. Several pseudogenes were also identified. The predicted MRG proteins contain transmembrane, extracellular, and cytoplasmic domains. A subset of MRGs was expressed in specific subpopulations of sensory neurons that detect painful stimuli. The expression patterns of these genes thus revealed an unexpected degree of molecular diversity among nociceptive neurons. Some MRGs could be specifically activated in heterologous cells by RFamide neuropeptides such as NPFF and NPAF, which are analgesic in vivo. The authors concluded that MRGs may regulate nociceptor function and/or development, including the sensation or modulation of pain.
Organism species: Homo sapiens (Human)
CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
Proteins | n/a | Recombinant MAS Related GPR Member X1 (MRGPRX1) | Recombinant Protein Customized Service Offer |
Antibodies | n/a | Monoclonal Antibody to MAS Related GPR Member X1 (MRGPRX1) | Monoclonal Antibody Customized Service Offer |
n/a | Polyclonal Antibody to MAS Related GPR Member X1 (MRGPRX1) | Polyclonal Antibody Customized Service Offer | |
Assay Kits | n/a | CLIA Kit for MAS Related GPR Member X1 (MRGPRX1) | CLIA Kit Customized Service Offer |
n/a | ELISA Kit for MAS Related GPR Member X1 (MRGPRX1) | ELISA Kit Customized Service Offer |
Organism species: Mus musculus (Mouse)
CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
Proteins | n/a | Recombinant MAS Related GPR Member X1 (MRGPRX1) | Recombinant Protein Customized Service Offer |
Antibodies | n/a | Monoclonal Antibody to MAS Related GPR Member X1 (MRGPRX1) | Monoclonal Antibody Customized Service Offer |
n/a | Polyclonal Antibody to MAS Related GPR Member X1 (MRGPRX1) | Polyclonal Antibody Customized Service Offer | |
Assay Kits | n/a | CLIA Kit for MAS Related GPR Member X1 (MRGPRX1) | CLIA Kit Customized Service Offer |
n/a | ELISA Kit for MAS Related GPR Member X1 (MRGPRX1) | ELISA Kit Customized Service Offer |
- "A diverse family of GPCRs expressed in specific subsets of nociceptive sensory neurons."Cell 106:619-632(2001) [PubMed] [Europe PMC] [Abstract]
- "Proenkephalin A gene products activate a new family of sensory neuron-specific GPCRs."Nat. Neurosci. 5:201-209(2002) [PubMed] [Europe PMC] [Abstract]
- "Identification of G protein-coupled receptor genes from the human genome sequence."FEBS Lett. 520:97-101(2002) [PubMed] [Europe PMC] [Abstract]
- "Human chromosome 11 DNA sequence and analysis including novel gene identification." Nature 440:497-500(2006) [PubMed] [Europe PMC] [Abstract]
- "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
- "Sensory neuron-specific GPCR Mrgprs are itch receptors mediating chloroquine-induced pruritus."Cell 139:1353-1365(2009) [PubMed] [Europe PMC] [Abstract]