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Caspase Recruitment Domain Family, Member 8 (CARD8)

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CARDINAL; DACAR; NDPP1; TUCAN; Apoptotic protein NDPP1; CARD-inhibitor of NF-kappa-B-activating ligand; Tumor up-regulated CARD-containing antagonist of CASP9

Caspase Recruitment Domain Family, Member 8 (CARD8)
CCC J915
HGNC 17057
PubMed 23611467
UniProt Q9Y2G2
Wiki CARD8
CARD8 belongs to the caspase recruitment domain (CARD)-containing family of proteins, which are involved in pathways leading to activation of caspases or nuclear factor kappa-B (NFKB). This protein may be a component of the inflammasome, a protein complex that plays a role in the activation of proinflammatory caspases. It is thought that this protein acts as an adaptor molecule that negatively regulates NFKB activation, CASP1-dependent IL1B secretion, and apoptosis. Polymorphisms in this gene may be associated with a susceptibility to rheumatoid arthritis. Alternatively spliced transcript variants have been described for this gene.High expression in lung, ovary, testis and placenta. Lower expression in heart, kidney and liver. Also expressed in spleen, lymph node and bone marrow.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Caspase Recruitment Domain Family, Member 8 (CARD8) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Caspase Recruitment Domain Family, Member 8 (CARD8) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Caspase Recruitment Domain Family, Member 8 (CARD8) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Caspase Recruitment Domain Family, Member 8 (CARD8) CLIA Kit Customized Service Offer
n/a ELISA Kit for Caspase Recruitment Domain Family, Member 8 (CARD8) ELISA Kit Customized Service Offer
  1. "Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."DNA Res. 6:63-70(1999) [PubMed] [Europe PMC] [Abstract]
  2. "CARD-8 protein, a new CARD family member that regulates caspase-1 activation and apoptosis."J. Biol. Chem. 277:13952-13958(2002) [PubMed] [Europe PMC] [Abstract]
  3. "NDPP1 is a novel CARD domain containing protein which can inhibit apoptosis and suppress NF-kappaB activation."Int. J. Oncol. 20:1035-1040(2002) [PubMed] [Europe PMC] [Abstract]
  4. "CARDINAL, a novel caspase recruitment domain protein, is an inhibitor of multiple NF-kappa B activation pathways."J. Biol. Chem. 276:44069-44077(2001) [PubMed] [Europe PMC] [Abstract]
  5. "Novel isoforms of the CARD8 (TUCAN) gene evade a nonsense mutation."Eur. J. Hum. Genet. 16:619-625(2008) [PubMed] [Europe PMC] [Abstract]
  6. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  7. "The DNA sequence and biology of human chromosome 19." Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
  8. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  9. "TUCAN, an antiapoptotic caspase-associated recruitment domain family protein overexpressed in cancer."J. Biol. Chem. 276:32220-32229(2001) [PubMed] [Europe PMC] [Abstract]
  10. "TUCAN/CARDINAL and DRAL participate in a common pathway for modulation of NF-kappaB activation."FEBS Lett. 521:165-169(2002) [PubMed] [Europe PMC] [Abstract]
  11. "NALP3 forms an IL-1beta-processing inflammasome with increased activity in Muckle-Wells autoinflammatory disorder."Immunity 20:319-325(2004) [PubMed] [Europe PMC] [Abstract]
  12. "The structure of the CARD8 caspase-recruitment domain suggests its association with the FIIND domain and procaspases through adjacent surfaces."Acta Crystallogr. F 69:482-487(2013) [PubMed] [Europe PMC] [Abstract]