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Salt Inducible Kinase 1 (SIK1)

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SNF1LK; Msk; Myocardial SNF1-Like Kinase; Serine/threonine-protein kinase SNF1-like kinase 1; Serine/threonine-protein kinase SIK1

Salt Inducible Kinase 1 (SIK1)
CCC J918
HGNC 11142
MGI 104754
PubMed 19622832
RGD 69407
UniProt P57059
Wiki SNF1LK
In Drosophila and C. elegans, signal transduction pathways initiated by the activation of receptor-protein tyrosine kinases can mediate developmental fate decisions. One, designated Hek2, encodes the mouse ortholog of human HEK2, a member of the eph receptor protein tyrosine kinase gene family. The other, designated msk (myocardial Snf1-like kinase), encodes a putative protein serine/threonine kinase most similar to the yeast protein Snf1, which is involved in the response to nutritional stress. Stephenson et al. (2004) found that Chinese hamster ovary cells expressing an inducible human SNF1LK kinase domain did not divide, but underwent additional rounds of replication to yield 8N and 16N cells. This data suggested a role for SNF1LK in G2/M regulation.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Salt Inducible Kinase 1 (SIK1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Salt Inducible Kinase 1 (SIK1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Salt Inducible Kinase 1 (SIK1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Salt Inducible Kinase 1 (SIK1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Salt Inducible Kinase 1 (SIK1) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Salt Inducible Kinase 1 (SIK1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Salt Inducible Kinase 1 (SIK1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Salt Inducible Kinase 1 (SIK1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Salt Inducible Kinase 1 (SIK1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Salt Inducible Kinase 1 (SIK1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Salt Inducible Kinase 1 (SIK1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Salt Inducible Kinase 1 (SIK1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Salt Inducible Kinase 1 (SIK1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Salt Inducible Kinase 1 (SIK1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Salt Inducible Kinase 1 (SIK1) ELISA Kit Customized Service Offer
  1. "LKB1 is a master kinase that activates 13 kinases of the AMPK subfamily, including MARK/PAR-1."EMBO J. 23:833-843(2004) [PubMed] [Europe PMC] [Abstract]
  2. "The DNA sequence of human chromosome 21." Nature 405:311-319(2000) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  5. "14-3-3 cooperates with LKB1 to regulate the activity and localization of QSK and SIK."J. Cell Sci. 118:5661-5673(2005) [PubMed] [Europe PMC] [Abstract]
  6. "Importance of autophosphorylation at Ser186 in the A-loop of salt inducible kinase 1 for its sustained kinase activity."J. Cell. Biochem. 104:1724-1739(2008) [PubMed] [Europe PMC] [Abstract]
  7. "Large-scale proteomics analysis of the human kinome."Mol. Cell. Proteomics 8:1751-1764(2009) [PubMed] [Europe PMC] [Abstract]
  8. "SIK1 couples LKB1 to p53-dependent anoikis and suppresses metastasis."Sci. Signal. 2:RA35-RA35(2009) [PubMed] [Europe PMC] [Abstract]
  9. "N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]
  10. "Patterns of somatic mutation in human cancer genomes." Nature 446:153-158(2007) [PubMed] [Europe PMC] [Abstract]