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Tumor Suppressor Candidate 3 (TUSC3)

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N33; OST3A; Oligosaccharyltransferase 3 Homolog A; Magnesium uptake/transporter TUSC3

Tumor Suppressor Candidate 3 (TUSC3)
CCC J950
HGNC 30242
MGI 1933134
PubMed 23404293
RGD 1303318
UniProt Q13454
Wiki TUSC3
TUSC3 is a candidate tumor suppressor gene. It is located within a homozygously deleted region of a metastatic prostate cancer. The gene is expressed in most nonlymphoid human tissues including prostate, lung, liver, and colon. Expression was also detected in many epithelial tumor cell lines. Two transcript variants encoding distinct isoforms have been identified for this gene.
The predicted 347-amino acid protein shares 43% identity with an anonymous C. elegans gene and 20% identity with the yeast OST3 gene. The protein is predicted to have 4 transmembrane domains and was expressed as a 1.5-kb mRNA in most nonlymphoid cells and tissues examined, including prostate, lung, liver, and colon.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Tumor Suppressor Candidate 3 (TUSC3) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Tumor Suppressor Candidate 3 (TUSC3) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Tumor Suppressor Candidate 3 (TUSC3) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Tumor Suppressor Candidate 3 (TUSC3) CLIA Kit Customized Service Offer
n/a ELISA Kit for Tumor Suppressor Candidate 3 (TUSC3) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Tumor Suppressor Candidate 3 (TUSC3) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Tumor Suppressor Candidate 3 (TUSC3) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Tumor Suppressor Candidate 3 (TUSC3) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Tumor Suppressor Candidate 3 (TUSC3) CLIA Kit Customized Service Offer
n/a ELISA Kit for Tumor Suppressor Candidate 3 (TUSC3) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Tumor Suppressor Candidate 3 (TUSC3) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Tumor Suppressor Candidate 3 (TUSC3) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Tumor Suppressor Candidate 3 (TUSC3) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Tumor Suppressor Candidate 3 (TUSC3) CLIA Kit Customized Service Offer
n/a ELISA Kit for Tumor Suppressor Candidate 3 (TUSC3) ELISA Kit Customized Service Offer
  1. "Structure and methylation-associated silencing of a gene within a homozygously deleted region of human chromosome band 8p22."Genomics 35:55-65(1996) [PubMed] [Europe PMC] [Abstract]
  2. "DNA sequence and analysis of human chromosome 8." Nature 439:331-335(2006) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  4. "Oligosaccharyltransferase isoforms that contain different catalytic STT3 subunits have distinct enzymatic properties."Mol. Cell 12:101-111(2003) [PubMed] [Europe PMC] [Abstract]
  5. "Oligosaccharyltransferase-subunit mutations in nonsyndromic mental retardation."Am. J. Hum. Genet. 82:1150-1157(2008) [PubMed] [Europe PMC] [Abstract]
  6. "A defect in the TUSC3 gene is associated with autosomal recessive mental retardation."Am. J. Hum. Genet. 82:1158-1164(2008) [PubMed] [Europe PMC] [Abstract]
  7. "Mammalian MagT1 and TUSC3 are required for cellular magnesium uptake and vertebrate embryonic development."Proc. Natl. Acad. Sci. U.S.A. 106:15750-15755(2009) [PubMed] [Europe PMC] [Abstract]
  8. "Structural basis of substrate specificity of human oligosaccharyl transferase subunit N33/Tusc3 and its role in regulating protein N-glycosylation."Structure 22:590-601(2014) [PubMed] [Europe PMC] [Abstract]
  9. "Diagnostic exome sequencing in persons with severe intellectual disability."N. Engl. J. Med. 367:1921-1929(2012) [PubMed] [Europe PMC] [Abstract]