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Prospero Homeobox Protein 1 (PROX1)

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Homeobox prospero-like protein PROX1

Prospero Homeobox Protein 1 (PROX1)
CCC J962
HGNC 9459
MGI 97772
PubMed 22833470
RGD 1306890
UniProt Q92786
Wiki PROX1
Comparison of the human and chicken PROX1 nucleotide sequence demonstrated that they are highly conserved, with overall homology of 94%. In the region of the homeodomain and the prospero domain, the genes were identical.
The prospero domain coincides with a domain in a Drosophila gene that is expressed in Drosophila central nervous system and in the developing lens-secreting cone cells of the eye. Exon 1 of the human sequence showed no clear similarity to the 3 alternatively spliced variants of chicken PROX1 cDNA. Human PROX1 exon 1 was found to contain repetitive sequences. Analysis of mRNA revealed that Prox mRNA was present in many different human tissues and that lens demonstrated the highest level. In all tissues but lens, PROX1 cDNA hybridized to a single band of 8 kb.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Prospero Homeobox Protein 1 (PROX1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Prospero Homeobox Protein 1 (PROX1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Prospero Homeobox Protein 1 (PROX1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Prospero Homeobox Protein 1 (PROX1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Prospero Homeobox Protein 1 (PROX1) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Prospero Homeobox Protein 1 (PROX1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Prospero Homeobox Protein 1 (PROX1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Prospero Homeobox Protein 1 (PROX1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Prospero Homeobox Protein 1 (PROX1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Prospero Homeobox Protein 1 (PROX1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Prospero Homeobox Protein 1 (PROX1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Prospero Homeobox Protein 1 (PROX1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Prospero Homeobox Protein 1 (PROX1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Prospero Homeobox Protein 1 (PROX1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Prospero Homeobox Protein 1 (PROX1) ELISA Kit Customized Service Offer
  1. "Structure and chromosomal localization of the human homeobox gene Prox 1."Genomics 35:517-522(1996) [PubMed] [Europe PMC] [Abstract]
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  3. "The DNA sequence and biological annotation of human chromosome 1." Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Transcription factor PROX1: its role in development and cancer."Cancer Metastasis Rev. 31:793-805(2012) [PubMed] [Europe PMC] [Abstract]
  6. "Prospero-related homeobox 1 (Prox1) functions as a novel modulator of retinoic acid-related orphan receptors alpha- and gamma-mediated transactivation."Nucleic Acids Res. 41:6992-7008(2013) [PubMed] [Europe PMC] [Abstract]
  7. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  8. "Determination of solution structures of proteins up to 40 kDa using CS-Rosetta with sparse NMR data from deuterated samples."Proc. Natl. Acad. Sci. U.S.A. 109:10873-10878(2012) [PubMed] [Europe PMC] [Abstract]