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Meis Homeobox Protein 2 (MEIS2)

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MRG1; Myeloid Ecotropic Viral Integration Site 1 Homolog 2; Meis1-related protein 1

Meis Homeobox Protein 2 (MEIS2)
CCC J990
HGNC 7001
MGI 108564
PubMed 22390724
UniProt O14770
Wiki MEIS2
MEIS2 encodes a homeobox protein belonging to the TALE ('three amino acid loop extension') family of homeodomain-containing proteins. TALE homeobox proteins are highly conserved transcription regulators, and several members have been shown to be essential contributors to developmental programs. Multiple transcript variants encoding distinct isoforms have been described for this gene.
Human MEIS2 was found to be expressed in various human tissues. In hematopoietic tissues, the lymphoid organs expressed high levels of MEIS2 as 2 transcripts of 4.0 kb and 3.5 kb. MEIS2 is also expressed in some regions of the brain, such as the putamen.In addition, the 3-prime untranslated region (UTR) of MEIS1 is remarkably conserved in evolution.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Meis Homeobox Protein 2 (MEIS2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Meis Homeobox Protein 2 (MEIS2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Meis Homeobox Protein 2 (MEIS2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Meis Homeobox Protein 2 (MEIS2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Meis Homeobox Protein 2 (MEIS2) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Meis Homeobox Protein 2 (MEIS2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Meis Homeobox Protein 2 (MEIS2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Meis Homeobox Protein 2 (MEIS2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Meis Homeobox Protein 2 (MEIS2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Meis Homeobox Protein 2 (MEIS2) ELISA Kit Customized Service Offer
  1. "Three-amino acid extension loop homeodomain proteins Meis2 and TGIF differentially regulate transcription."J. Biol. Chem. 275:20734-20741(2000) [PubMed] [Europe PMC] [Abstract]
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  3. "Analysis of the DNA sequence and duplication history of human chromosome 15." Nature 440:671-675(2006) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Chromosomal mapping to 15q14 and expression analysis of the human MEIS2 homeobox gene."Mamm. Genome 8:951-952(1997) [PubMed] [Europe PMC] [Abstract]
  6. "DNA binding and transcriptional activation by a PDX1.PBX1b.MEIS2b trimer and cooperation with a pancreas-specific basic helix-loop-helix complex."J. Biol. Chem. 276:17985-17993(2001) [PubMed] [Europe PMC] [Abstract]
  7. "Spatiotemporal distribution of PAX6 and MEIS2 expression and total cell numbers in the ganglionic eminence in the early developing human forebrain."Dev. Neurosci. 32:149-162(2010) [PubMed] [Europe PMC] [Abstract]
  8. "An autoinhibitory effect of the homothorax domain of Meis2."FEBS J. 277:2584-2597(2010) [PubMed] [Europe PMC] [Abstract]
  9. "MEIS proteins as partners of the TLX1/HOX11 oncoprotein."Leuk. Res. 34:358-363(2010) [PubMed] [Europe PMC] [Abstract]
  10. "Cooperative transcriptional activation by Klf4, Meis2, and Pbx1."Mol. Cell. Biol. 31:3723-3733(2011) [PubMed] [Europe PMC] [Abstract]