1-Acylglycerol-3-Phosphate-O-Acyltransferase 6 (AGPAT6)

Lysophosphatidic acid acyltransferases (EC 2.3.1.51) catalyze the conversion of lysophosphatidic acid (LPA) to phosphatidic acid (PA). LPA and PA are involved in signal transduction and lipid biosynthesis.

The deduced 456-amino acid protein has a calculated molecular mass of 52.1 kD. LPAAT-zeta contains an N-terminal signal peptide, an acyltransferase domain containing 2 conserved motifs, and 4 putative transmembrane regions. Within the enzymatic domain, LPAAT-zeta shares 17 to 21% identity with the corresponding domains of other LPAAT family members. Northern blot analysis detected transcripts of 3.0, 4.3, and 4.6 kb in all tissues examined. Highest expression was found in skeletal muscle, heart, and testis. A transcript of 2.7 kb was also detected in testis.