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N-Alpha-Acetyltransferase 10 (NaA10)

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ARD1; ARD1A; TE2; NatA catalytic subunit Naa10; N(alpha)-Acetyltransferase 10,NatA Catalytic Subunit; N-terminal acetyltransferase complex ARD1 subunit homolog A

N-Alpha-Acetyltransferase 10 (NaA10)
CCC K047
HGNC 18704
MGI 1915255
PubMed 24431331
RGD 1565315
UniProt P41227
N-alpha-acetylation is one of the most common protein modifications that occurs during protein synthesis and involves the transfer of an acetyl group from acetyl-coenzyme A to the protein alpha-amino group. ARD1A, together with NATH (NARG1), is part of a major N-alpha-acetyltransferase complex responsible for alpha-acetylation of proteins and peptides.Three new genes were identified and positioned. One of these, termed TE2, demonstrated 40% identity with the ARD1 protein of Saccharomyces cerevisiae, a protein required for the expression of an N-terminal protein acetyltransferase activity.The 235-amino acid protein contains an N-acetyltransferase domain, a highly conserved acetyl-coenzyme A binding motif, and a C-terminal APP-binding domain.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant N-Alpha-Acetyltransferase 10 (NaA10) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to N-Alpha-Acetyltransferase 10 (NaA10) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to N-Alpha-Acetyltransferase 10 (NaA10) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for N-Alpha-Acetyltransferase 10 (NaA10) CLIA Kit Customized Service Offer
n/a ELISA Kit for N-Alpha-Acetyltransferase 10 (NaA10) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant N-Alpha-Acetyltransferase 10 (NaA10) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to N-Alpha-Acetyltransferase 10 (NaA10) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to N-Alpha-Acetyltransferase 10 (NaA10) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for N-Alpha-Acetyltransferase 10 (NaA10) CLIA Kit Customized Service Offer
n/a ELISA Kit for N-Alpha-Acetyltransferase 10 (NaA10) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant N-Alpha-Acetyltransferase 10 (NaA10) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to N-Alpha-Acetyltransferase 10 (NaA10) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to N-Alpha-Acetyltransferase 10 (NaA10) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for N-Alpha-Acetyltransferase 10 (NaA10) CLIA Kit Customized Service Offer
n/a ELISA Kit for N-Alpha-Acetyltransferase 10 (NaA10) ELISA Kit Customized Service Offer
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  2. "Identification and characterization of the human ARD1-NATH protein acetyltransferase complex."Biochem. J. 386:433-443(2005) [PubMed] [Europe PMC] [Abstract]
  3. "The DNA sequence of the human X chromosome." Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract]
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  6. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
  7. "Cloning and characterization of hNAT5/hSAN: an evolutionarily conserved component of the NatA protein N-alpha-acetyltransferase complex."Gene 371:291-295(2006) [PubMed] [Europe PMC] [Abstract]
  8. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  9. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
  10. "A novel human NatA Nalpha-terminal acetyltransferase complex: hNaa16p-hNaa10p (hNat2-hArd1)."BMC Biochem. 10:15-15(2009) [PubMed] [Europe PMC] [Abstract]
  11. "A synopsis of eukaryotic Nalpha-terminal acetyltransferases: nomenclature, subunits and substrates."BMC Proc. 3:S2-S2(2009) [PubMed] [Europe PMC] [Abstract]
  12. "Phosphorylation of ARD1 by IKKbeta contributes to its destabilization and degradation."Biochem. Biophys. Res. Commun. 389:156-161(2009) [PubMed] [Europe PMC] [Abstract]
  13. "Arrest defective-1 controls tumor cell behavior by acetylating myosin light chain kinase."PLoS ONE 4:E7451-E7451(2009) [PubMed] [Europe PMC] [Abstract]
  14. "The chaperone-like protein HYPK acts together with NatA in cotranslational N-terminal acetylation and prevention of Huntingtin aggregation."Mol. Cell. Biol. 30:1898-1909(2010) [PubMed] [Europe PMC] [Abstract]
  15. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  16. "ARD1 stabilization of TSC2 suppresses tumorigenesis through the mTOR signaling pathway." Sci. Signal. 3:RA9-RA9(2010) [PubMed] [Europe PMC] [Abstract]
  17. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  18. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  19. "A splice donor mutation in NAA10 results in the dysregulation of the retinoic acid signalling pathway and causes Lenz microphthalmia syndrome."J. Med. Genet. 51:185-196(2014) [PubMed] [Europe PMC] [Abstract]
  20. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  21. "Using VAAST to identify an X-linked disorder resulting in lethality in male infants due to N-terminal acetyltransferase deficiency." Am. J. Hum. Genet. 89:28-43(2011) [PubMed] [Europe PMC] [Abstract]