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Methylphosphate Capping Enzyme (MEPCE)

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BCDIN3; Bin3,Bicoid-Interacting 3; Bicoid-interacting protein 3 homolog; 7SK snRNA methylphosphate capping enzyme

Methylphosphate Capping Enzyme (MEPCE)
CCC K062
HGNC 20247
MGI 106477
PubMed 23471002
RGD 1560550
UniProt Q7L2J0
Gel filtration confirmed that P-TEFb, HEXIM1, and SART3 cofractionated with MEPCE, and RNA blot analysis showed that 7SK (RN7SK) and U6 (RNU6) small nuclear RNAs were also present in the complex. In the presence of radiolabeled S-adenosyl methionine, recombinant MEPCE methylated recombinant 7SK in vitro. MEPCE required 5-prime phosphates of 7SK, demonstrating that MEPCE is a 7SK methylphosphate capping enzyme. Silencing of MEPCE by small interfering RNA decreased the steady-state level of cellular 7SK, suggesting that MEPCE stabilizes 7SK by adding a methylphosphate cap at its 5-prime end.deduced 689-amino acid protein has a central RNA methylase domain and a C-terminal Bin3 domain. Database analysis revealed homologs of MEPCE in both higher and lower eukaryotes.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Methylphosphate Capping Enzyme (MEPCE) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Methylphosphate Capping Enzyme (MEPCE) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Methylphosphate Capping Enzyme (MEPCE) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Methylphosphate Capping Enzyme (MEPCE) CLIA Kit Customized Service Offer
n/a ELISA Kit for Methylphosphate Capping Enzyme (MEPCE) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Methylphosphate Capping Enzyme (MEPCE) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Methylphosphate Capping Enzyme (MEPCE) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Methylphosphate Capping Enzyme (MEPCE) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Methylphosphate Capping Enzyme (MEPCE) CLIA Kit Customized Service Offer
n/a ELISA Kit for Methylphosphate Capping Enzyme (MEPCE) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Methylphosphate Capping Enzyme (MEPCE) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Methylphosphate Capping Enzyme (MEPCE) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Methylphosphate Capping Enzyme (MEPCE) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Methylphosphate Capping Enzyme (MEPCE) CLIA Kit Customized Service Offer
n/a ELISA Kit for Methylphosphate Capping Enzyme (MEPCE) ELISA Kit Customized Service Offer
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  20. "Methyltransferase domain of human bicoid-interacting protein 3 homolog (drosophila)."Submitted (MAY-2009) to the PDB data bank