≡

Dynamin 1 Like Protein (DNM1L)

[Edit]

DRP1; DLP1; DVLP; DYMPLE; HDYNIV; VPS1; Dynamin-related protein 1; Dnm1p/Vps1p-like protein; Dynamin family member proline-rich carboxyl-terminal domain less

Dynamin 1 Like Protein (DNM1L)
CCC K069
HGNC 2973
MGI 1921256
PubMed 20585624
RGD 620416
UniProt O00429
Wiki DNM1L
DNM1L is a member of the dynamin superfamily of GTPases. Members of the dynamin-related subfamily, including the S. cerevisiae proteins Dnm1 and Vps1, contain the N-terminal tripartite GTPase domain but do not have the pleckstrin homology or proline-rich domains.
This protein establishes mitochondrial morphology through a role in distributing mitochondrial tubules throughout the cytoplasm. The gene has 3 alternatively spliced transcripts encoding different isoforms. DVLP contains the highly conserved N-terminal tripartite GTP-binding domain, but it lacks the pleckstrin homology domain and proline-rich region. It shares 45% and 42% amino acid identity with yeast Dnm1 and Vps1, respectively.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Dynamin 1 Like Protein (DNM1L) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Dynamin 1 Like Protein (DNM1L) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Dynamin 1 Like Protein (DNM1L) Polyclonal Antibody Customized Service Offer
Assay Kits SEK069Hu ELISA Kit for Dynamin 1 Like Protein (DNM1L) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Dynamin 1 Like Protein (DNM1L) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Dynamin 1 Like Protein (DNM1L) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Dynamin 1 Like Protein (DNM1L) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Dynamin 1 Like Protein (DNM1L) CLIA Kit Customized Service Offer
n/a ELISA Kit for Dynamin 1 Like Protein (DNM1L) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Dynamin 1 Like Protein (DNM1L) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Dynamin 1 Like Protein (DNM1L) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Dynamin 1 Like Protein (DNM1L) Polyclonal Antibody Customized Service Offer
Assay Kits SEK069Ra ELISA Kit for Dynamin 1 Like Protein (DNM1L) Enzyme-linked immunosorbent assay for Antigen Detection.
  1. "Identification and subcellular localization of a novel mammalian dynamin-related protein homologous to yeast Vps1p and Dnm1p."J. Biochem. 122:525-530(1997) [PubMed] [Europe PMC] [Abstract]
  2. "Human dynamin-like protein interacts with the glycogen synthase kinase 3beta."Biochem. Biophys. Res. Commun. 249:697-703(1998) [PubMed] [Europe PMC] [Abstract]
  3. "Identification and functional characterization of a novel human protein highly related to the yeast dynamin-like GTPase Vps1p."J. Cell Sci. 111:1341-1349(1998) [PubMed] [Europe PMC] [Abstract]
  4. "Differential expression of four human dynamin-like protein variants in brain tumors."DNA Cell Biol. 19:189-194(2000) [PubMed] [Europe PMC] [Abstract]
  5. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  6. "The finished DNA sequence of human chromosome 12." Nature 440:346-351(2006) [PubMed] [Europe PMC] [Abstract]
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  8. "Dymple, a novel dynamin-like high molecular weight GTPase lacking a proline-rich carboxyl-terminal domain in mammalian cells."J. Biol. Chem. 273:1044-1051(1998) [PubMed] [Europe PMC] [Abstract]
  9. "A novel dynamin-like protein associates with cytoplasmic vesicles and tubules of the endoplasmic reticulum in mammalian cells."J. Cell Biol. 140:779-793(1998) [PubMed] [Europe PMC] [Abstract]
  10. "A human dynamin-related protein controls the distribution of mitochondria."J. Cell Biol. 143:351-358(1998) [PubMed] [Europe PMC] [Abstract]
  11. "Intermolecular and interdomain interactions of a dynamin-related GTP-binding protein, Dnm1p/Vps1p-like protein."J. Biol. Chem. 274:2780-2785(1999) [PubMed] [Europe PMC] [Abstract]
  12. "Dynamin-related protein Drp1 is required for mitochondrial division in mammalian cells."Mol. Biol. Cell 12:2245-2256(2001) [PubMed] [Europe PMC] [Abstract]
  13. "Dynamin-like protein 1 is involved in peroxisomal fission."J. Biol. Chem. 278:8597-8605(2003) [PubMed] [Europe PMC] [Abstract]
  14. "The dynamin-like GTPase DLP1 is essential for peroxisome division and is recruited to peroxisomes in part by PEX11."J. Biol. Chem. 278:17012-17020(2003) [PubMed] [Europe PMC] [Abstract]
  15. "Intra- and intermolecular domain interactions of the C-terminal GTPase effector domain of the multimeric dynamin-like GTPase Drp1."J. Biol. Chem. 279:35967-35974(2004) [PubMed] [Europe PMC] [Abstract]
  16. "A novel mitochondrial ubiquitin ligase plays a critical role in mitochondrial dynamics."EMBO J. 25:3618-3626(2006) [PubMed] [Europe PMC] [Abstract]
  17. "MARCH-V is a novel mitofusin 2- and Drp1-binding protein able to change mitochondrial morphology."EMBO Rep. 7:1019-1022(2006) [PubMed] [Europe PMC] [Abstract]
  18. "Inhibiting the mitochondrial fission machinery does not prevent Bax/Bak-dependent apoptosis."Mol. Cell. Biol. 26:7397-7408(2006) [PubMed] [Europe PMC] [Abstract]
  19. "Mitotic phosphorylation of dynamin-related GTPase Drp1 participates in mitochondrial fission."J. Biol. Chem. 282:11521-11529(2007) [PubMed] [Europe PMC] [Abstract]
  20. "Cyclic AMP-dependent protein kinase phosphorylation of Drp1 regulates its GTPase activity and mitochondrial morphology."J. Biol. Chem. 282:21583-21587(2007) [PubMed] [Europe PMC] [Abstract]
  21. "The mitochondrial E3 ubiquitin ligase MARCH5 is required for Drp1 dependent mitochondrial division."J. Cell Biol. 178:71-84(2007) [PubMed] [Europe PMC] [Abstract]
  22. "A lethal defect of mitochondrial and peroxisomal fission."N. Engl. J. Med. 356:1736-1741(2007) [PubMed] [Europe PMC] [Abstract]
  23. "CaM kinase I alpha-induced phosphorylation of Drp1 regulates mitochondrial morphology."J. Cell Biol. 182:573-585(2008) [PubMed] [Europe PMC] [Abstract]
  24. "Phosphoproteome of resting human platelets."J. Proteome Res. 7:526-534(2008) [PubMed] [Europe PMC] [Abstract]
  25. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  26. "Dephosphorylation by calcineurin regulates translocation of Drp1 to mitochondria."Proc. Natl. Acad. Sci. U.S.A. 105:15803-15808(2008) [PubMed] [Europe PMC] [Abstract]
  27. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
  28. "MAPL is a new mitochondrial SUMO E3 ligase that regulates mitochondrial fission."EMBO Rep. 10:748-754(2009) [PubMed] [Europe PMC] [Abstract]
  29. "SUMOylation of the mitochondrial fission protein Drp1 occurs at multiple nonconsensus sites within the B domain and is linked to its activity cycle."FASEB J. 23:3917-3927(2009) [PubMed] [Europe PMC] [Abstract]
  30. "Translocation of SenP5 from the nucleoli to the mitochondria modulates DRP1-dependent fission during mitosis."J. Biol. Chem. 284:17783-17795(2009) [PubMed] [Europe PMC] [Abstract]
  31. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  32. "S-nitrosylation of Drp1 mediates beta-amyloid-related mitochondrial fission and neuronal injury."Science 324:102-105(2009) [PubMed] [Europe PMC] [Abstract]
  33. "Dynamin-like protein 1 at the Golgi complex: A novel component of the sorting/targeting machinery en route to the plasma membrane."Exp. Cell Res. 316:3454-3467(2010) [PubMed] [Europe PMC] [Abstract]
  34. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  35. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  36. "MiD49 and MiD51, new components of the mitochondrial fission machinery."EMBO Rep. 12:565-573(2011) [PubMed] [Europe PMC] [Abstract]
  37. "Human MIEF1 recruits Drp1 to mitochondrial outer membranes and promotes mitochondrial fusion rather than fission."EMBO J. 30:2762-2778(2011) [PubMed] [Europe PMC] [Abstract]
  38. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  39. "The mitochondrial phosphatase PGAM5 functions at the convergence point of multiple necrotic death pathways."Cell 148:228-243(2012) [PubMed] [Europe PMC] [Abstract]
  40. "Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features."Mol. Cell. Proteomics 11:M111.015131-M111.015131(2012) [PubMed] [Europe PMC] [Abstract]
  41. "MiD49 and MiD51 can act independently of Mff and Fis1 in Drp1 recruitment and are specific for mitochondrial fission."J. Biol. Chem. 288:27584-27593(2013) [PubMed] [Europe PMC] [Abstract]
  42. "Fis1, Mff, MiD49, and MiD51 mediate Drp1 recruitment in mitochondrial fission."Mol. Biol. Cell 24:659-667(2013) [PubMed] [Europe PMC] [Abstract]
  43. "A Bcl-xL-Drp1 complex regulates synaptic vesicle membrane dynamics during endocytosis."Nat. Cell Biol. 15:773-785(2013) [PubMed] [Europe PMC] [Abstract]
  44. "Interchangeable adaptors regulate mitochondrial dynamin assembly for membrane scission."Proc. Natl. Acad. Sci. U.S.A. 110:E1342-E1351(2013) [PubMed] [Europe PMC] [Abstract]
  45. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  46. "Structural insights into oligomerization and mitochondrial remodelling of dynamin 1-like protein."EMBO J. 32:1280-1292(2013) [PubMed] [Europe PMC] [Abstract]
  47. "Functional mapping of human dynamin-1-like GTPase domain based on x-ray structure analyses."PLoS ONE 8:E71835-E71835(2013) [PubMed] [Europe PMC] [Abstract]