Polycystic Kidney Disease 2 Like Protein 1 (PKD2L1)

PKD2L1 encodes a member of the polycystin protein family. The encoded protein contains multiple transmembrane domains, and cytoplasmic N- and C-termini. The protein may be an integral membrane protein involved in cell-cell/matrix interactions. This protein functions as a calcium-regulated nonselective cation channel. Alternative splice variants have been described but their full length sequences have not been determined.PKDL contains 16 exons and undergoes alternative splicing. PKD2L is expressed in adult heart and skeletal muscle, brain, spleen, testis, and retina. They observed alternative transcripts of 2.4, 2.7, and 3.0 kb. PKD2L protein showed 56% identity with polycystin-2 over a 581-amino acid span; however, the C-terminal 65 residues of PKD2L are unrelated to PKD2.