Polycystic Kidney Disease 2 Like Protein 2 (PKD2L2)

Polycystin-1 and polycystin-2, encoded by the PKD1 and PKD2 genes, respectively, are mutated in the majority of patients with autosomal dominant polycystic kidney disease. By searching databases for sequences related to PKD1 or PKD2 and using 5-prime and 3-prime RACE, Veldhuisen et al. (1999) obtained a testis cDNA homolog of PKD2, which they designated PKD2L2. The PKD2L2 cDNA encodes a deduced protein of 613 amino acids that is 48% identical and 67% similar to both PKD2 and PKD2L1. Sequence analysis predicted that PKD2L2 has 6 to 8 transmembrane domains, 2 cation channel motifs, and a channel pore calcium sodium motif. In contrast to PKD2, it has no putative EF-hand or coiled-coil domains. TRPP3 is a member of the transient receptor potential channel family of proteins.