Polycystic Kidney Disease 1 Like Protein 2 (PKD1L2)

The deduced 2,459-amino acid PKD1L2 protein contains an N-terminal C-type lectin domain, followed by a pair of PKD domains, a receptor egg jelly domain, a central GPCR proteolytic site and PLAT domain, and a C-terminal putative channel pore region. It also has 11 transmembrane domains. RT-PCR detected several alternative splice forms that are generated by exon skipping. Northern blot analysis revealed expression of a 9.8-kb transcript only in skeletal muscle.

PKD1L2, which is translated from a start codon within exon 12 and encodes a deduced 1,175-amino acid protein. PKD1L2 expression was below the level of detection by Northern blot analysis. RNA dot blot analysis detected moderate expression in adult and fetal heart, mammary gland, and brain, and lower expression in testis.